ABSTRACT
OBJECTIVE: An automated cognitive neurophysiological test is presented that characterizes how an individual was affected by a drug or treatment. The test calculates sub-scores for working memory task performance, cortical activation, and alertness, and combines the sub-scores into an overall score. METHODS: The test was applied in a double-blind, placebo-controlled study of alcohol, caffeine, diphenhydramine, and sleep deprivation in 16 healthy adults. RESULTS: The between- and within-day variability of the sub-scores and overall scores for placebo were all near zero, suggesting that the scores are stable. All treatments affected the overall score, while differential effects on sub-scores highlighted the added value of EEG measures. CONCLUSIONS: The test is sensitive to relatively mild alterations in cognitive function. Its automation makes it suitable for use in large-scale clinical trials. SIGNIFICANCE: By combining task performance with EEG brain function measures, the test may prove to have better sensitivity and specificity in detecting changes due to drugs or other treatments than comparable neuropsychological test batteries that do not directly measure brain function signals.
Subject(s)
Cognition Disorders/diagnosis , Cognition/physiology , Electroencephalography/methods , Memory Disorders/diagnosis , Neuropsychological Tests/standards , Adolescent , Adult , Aged , Cognition/drug effects , Cognition Disorders/chemically induced , Cognition Disorders/physiopathology , Cross-Over Studies , Double-Blind Method , Electroencephalography/drug effects , Female , Humans , Male , Memory Disorders/chemically induced , Memory Disorders/physiopathology , Middle Aged , Young AdultABSTRACT
Working with highly pathogenic agents such as Ebola or Marburg virus in the context of infection control or biodefense research requires high-biocontainment laboratories of the Biosafety Level 4 (BSL-4) to protect researchers and laboratory staff from infection and to prevent the unintentional release of harmful agents. The public perception of research on highly pathogenic agents and the operation of high-containment facilities is often ambivalent: while the output of the biomedical research is highly valued, the existence of a BSL-4 lab is often viewed with concern. Biomedical research perspectives and public perceptions often differ and can lead to tensions that could have negative effects on research, society, and politics. Therefore, risk communication plays a crucial role in siting, building, and operating a high-containment facility. The Japanese government invited risk communication experts and scientists from Canada, the U.S., Europe, and Australia to discuss their risk communication strategies for BSL-4 labs. This article describes the international perspective on risk communication and gives recommendations for successful strategies.
