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J Med Toxicol ; 9(1): 71-4, 2013 Mar.
Article in English | MEDLINE | ID: mdl-22961673

ABSTRACT

INTRODUCTION: Sodium hypochlorite is the active ingredient in bleach, a ubiquitous household disinfectant, and has known toxicities depending on route of exposure and amount. Acute kidney injury due to sodium hypochlorite exposure has never been reported. Patients that did develop nephrotoxicity following bleach exposure did so due to development of other risk factors for kidney injury such as volume depletion or sepsis. DISCUSSION: We report a patient who presented with black urine after parenteral self-administration of a large quantity of bleach. We review the clinical presentation, laboratory and biopsy findings, and outcome as well as discuss possible mechanisms of sodium hypochlorite toxicity and management strategies.


Subject(s)
Acute Kidney Injury/chemically induced , Bleaching Agents/poisoning , Kidney/drug effects , Renal Insufficiency/etiology , Sodium Hypochlorite/poisoning , Acute Kidney Injury/pathology , Acute Kidney Injury/therapy , Adolescent , Female , Humans , Injections, Intravenous , Kidney/pathology , Recovery of Function , Renal Dialysis , Renal Insufficiency/pathology , Renal Insufficiency/therapy , Suicide, Attempted , Treatment Outcome
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