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1.
Eur J Obstet Gynecol Reprod Biol ; 299: 143-147, 2024 Jun 07.
Article in English | MEDLINE | ID: mdl-38865741

ABSTRACT

OBJECTIVE: Prevalence of obesity in reproductive age and pregnant women has been on the rise during the past several decades. The relationship between body mass index (BMI) and obstetric anal sphincter injuries (OASIS) or episiotomy has not yet been thoroughly investigated. The objective of this study was to shed light on this issue. METHODS: This retrospective cohort study was performed using electronic database of an obstetrics department at a university-affiliated tertiary medical center. All spontaneous singleton vaginal deliveries at term between January 2015 and December 2021 were included. The primary outcome was the incidence of OASIS (third- and fourth-degree perineal tears) and obesity. These were compared across three BMI categories: normal (BMI below 25 kg/m2), overweight (BMI 25.0-29.9 kg/m2), and obesity (BMI of 30 kg/m2 and over). RESULTS: Of the overall 13,932 spontaneous vaginal deliveries identified, 34.7 % had BMI in the normal range, 43.1 % were overweight, and 25.4 % were obese. Multivariate analysis demonstrated lower rates of OASIS in obese (OR 0.2, 95 %CI 0.04-0.9) and in overweight (OR 0.3, 95 %CI 0.1-0.99) women, as compared to the normal-weight cohort. In addition, lower rates of episiotomy were noted in the obese cohort (OR 0.7, 95 %CI 0.6-0.8). CONCLUSIONS: Decreased incidence of OASIS was noted in women with obesity, in conjunction with lower use of episiotomy. These findings imply that obstetrics clinics might consider a more conservative approach to episiotomy in obese patients.

3.
Isr Med Assoc J ; 26(3): 169-173, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38493328

ABSTRACT

BACKGROUND: Obliterative vaginal procedures may offer lower perioperative morbidity and equal success rates as reconstructive procedures for frail and elderly women who no longer desire future coital function. The combination of vaginal hysterectomy with either reconstructive or obliterative vaginal procedures has not yet been investigated. OBJECTIVES: To compare peri- and postoperative outcomes of vaginal hysterectomy with pelvic floor reconstruction (VHR) vs. vaginal hysterectomy with colpocleisis (VHC). METHODS: We conducted a retrospective study comparing medical and surgical data of patients undergoing either VHR or VHC between 2006 and 2015. Data were obtained from inpatient and outpatient medical records including peri- and postoperative course, as well as long-term (24 months) follow-up data. RESULTS: We identified 172 patients who underwent VHR and 44 who underwent VHC. Patients in the VHC group were significantly older (71.3 ± 4.5 vs. 68.6 ± 6.5 years, P = 0.01), and more likely to have medical co-morbidities (P = 0.001 and P = 0.029, respectively). Patients in the VHC group experienced shorter operative time (2.3 ± 0.58 vs. 2.7 ± 1.02 hours, P = 0.007), lower perioperative blood loss (P < 0.0001), shorter hospital stay (P < 0.0001), and lower rates of postoperative urinary retention. Long-term pelvic organ prolapse (POP) recurrence rates were significantly higher among the VHR group. Postoperative resolution of both stress urinary incontinence and overactive bladder were common in both groups. CONCLUSIONS: VHC is associated with lower perioperative blood loss, shorter operative time, shorter hospital stay, shorter time with an indwelling catheter, and lower long-term objective POP recurrence rates.


Subject(s)
Hysterectomy, Vaginal , Pelvic Organ Prolapse , Humans , Female , Aged , Hysterectomy, Vaginal/methods , Gynecologic Surgical Procedures/adverse effects , Gynecologic Surgical Procedures/methods , Retrospective Studies , Blood Loss, Surgical , Pelvic Organ Prolapse/surgery , Treatment Outcome
4.
Int J Gynaecol Obstet ; 164(3): 848-856, 2024 Mar.
Article in English | MEDLINE | ID: mdl-37488940

ABSTRACT

BACKGROUND: Studies aimed to assess risk factors for pelvic organ prolapse (POP) recurrence following colpocleisis with nonconclusive results. OBJECTIVE: To investigate risk factors for POP recurrence following colpocleisis. SEARCH STRATEGY: MEDLINE, PUBMED, Embase, Web of Science, and Cochrane databases were systematically searched. SELECTION CRITERIA: Experimental and non-experimental studies investigating POP recurrence following colpocleisis. DATA COLLECTION AND ANALYSIS: We assessed the association between preoperative and postoperative physical examination findings, demographics and medical history, and the risk of recurrence following colpocleisis. MAIN RESULTS: A total of 954 studies were identified, of which five studies comprising 2978 patients were eligible for analysis. Both preoperative and postoperative genital hiatus length were significantly longer in the recurrence group (mean difference [MD] 0.48, 95% confidence interval [CI] 0.01-0.94, P = 0.04, I2 = 0% and MD 1.15, 95% CI 0.50-1.81, P = 0.005, I2 = 0%; respectively). Preoperative total vaginal length (TVL) did not differ between groups (MD 0.05, 95% CI -0.40 to 0.50, P = 0.83, I2 = 6%), postoperative TVL was found significantly longer in the recurrence group (MD 0.07, 95% CI -0.03 to 1.38, P = 0.04, I2 = 68%). Both preoperative and postoperative perineal body did not differ between groups. Women with a previous POP surgery were more likely to experience recurrence following colpocleisis (relative risk 2.09, 95% CI 1.18-3.69, P = 0.01, I2 = 0%). Patient's age and previous hysterectomy did not affect recurrence rates. CONCLUSION: Wider preoperative and postoperative genital hiatus as well as longer post-operative TVL and previous POP surgery were associated with a higher risk for recurrence following colpocleisis, highlighting the importance of appropriate patient selection and surgical technique in minimizing this risk.


Subject(s)
Colpotomy , Pelvic Organ Prolapse , Pregnancy , Humans , Female , Colpotomy/methods , Vagina/surgery , Pelvic Organ Prolapse/surgery , Pelvic Organ Prolapse/complications , Hysterectomy , Risk Factors , Treatment Outcome , Gynecologic Surgical Procedures/adverse effects , Gynecologic Surgical Procedures/methods , Recurrence
5.
Am J Obstet Gynecol ; 230(3): 308-314.e5, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38036163

ABSTRACT

OBJECTIVE: This study aimed to assess the risk of stress urinary incontinence recurrence and reoperation after a midurethral sling procedure in women with subsequent childbirth and to assess the effect of delivery mode on this risk. DATA SOURCES: An electronic database search was performed using MEDLINE with the OvidSP interface and PubMed, Embase, Web of Science, and the Cochrane Library up to September 20, 2023. STUDY ELIGIBILITY CRITERIA: This study included experimental and nonexperimental studies, composed of randomized controlled and observational (case-control, cohort, and cross-sectional) studies assessing the risk factors for stress urinary incontinence recurrence and reoperation after childbirth in women who had previously undergone a midurethral sling procedure for stress urinary incontinence. METHODS: Analysis was performed using RevMan (version 5.3; Cochrane Collaboration, Oxford, United Kingdom). Quantitative synthesis was used if the included studies were sufficient in numbers and homogeneity. The overall certainty of the evidence was assessed using criteria recommended by the Grading of Recommendations Assessment, Development, and Evaluation Working Group. RESULTS: A total of 2001 studies were identified, of which 6 were eligible for analysis, composed of 381 patients who had at least 1 childbirth after a midurethral sling procedure (study group) and 860 patients who underwent a midurethral sling without having a subsequent childbirth (control group). All included studies were observational, the patients' mean age at the time of the midurethral sling procedure ranged from 34 to 36 years, and the mean time from midurethral sling procedure to delivery ranged from 21 to 31 months. No difference in stress urinary incontinence recurrence (relative risk, 0.1.02; 95% confidence interval, 0.78-1.33) or reoperation (relative risk, 1.37; 95% confidence interval, 0.87-2.17) was found between the study and control groups. The average follow-up time among the included studies of this comparison was 9.8 years (range, 2-18). Furthermore, the mode of delivery (vaginal vs cesarean) did not seem to affect the risk of stress urinary incontinence recurrence. CONCLUSION: Subsequent pregnancy and childbirth did not increase the risk of stress urinary incontinence recurrence or reoperation after a midurethral sling procedure.


Subject(s)
Suburethral Slings , Urinary Incontinence, Stress , Pregnancy , Humans , Female , Child, Preschool , Urinary Incontinence, Stress/surgery , Urinary Incontinence, Stress/etiology , Suburethral Slings/adverse effects , Cross-Sectional Studies , Reoperation , Risk Factors , Randomized Controlled Trials as Topic , Observational Studies as Topic
6.
Eur J Obstet Gynecol Reprod Biol ; 293: 91-94, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38134609

ABSTRACT

OBJECTIVE: To examine the association between the O blood type and bleeding tendency in patient undergoing vaginal hysterectomy. METHODS: This was a retrospective cohort study including all women who had undergone vaginal hysterectomy at our institution between January 2015 and September 2020. All women underwent blood type and complete blood count testing pre- and post-operatively. The estimated intraoperative blood loss, the need for blood transfusion, pre- and postoperative hemoglobin and hematocrit measurements and surgical data were recorded for all patients. Patients with known coagulopathies or those taking antithrombotic medications were excluded from the study. Statistical analysis was performed using student t, χ2, Fischer exact, and ANOVA tests as well as a stepwise logistic regression model. RESULTS: The study included 106 patients (35.2 %) with O and 195 patients (64.8 %) with non-O (i.e., A, B or AB) blood types. The O blood type was significantly associated with a higher risk for moderate blood loss (defined as a pre- to postoperative Hb or HCT drop >2gr or >6 %, respectively) (p = 0.012), but not with severe (defined as a Hb or HCT drop of >3gr or >9 %, respectively) perioperative bleeding, nor with the need for blood transfusion. CONCLUSION: The O blood type was found to be significantly associated with moderate but not with severe intraoperative bleeding during and following vaginal hysterectomy.


Subject(s)
Hysterectomy, Vaginal , Hysterectomy , Humans , Female , Hysterectomy, Vaginal/adverse effects , Hysterectomy/adverse effects , Retrospective Studies , Postoperative Complications/etiology , Blood Loss, Surgical
7.
Isr Med Assoc J ; 25(1): 59-63, 2023 Jan.
Article in English | MEDLINE | ID: mdl-36718739

ABSTRACT

BACKGROUND: Diagnosing occult stress urinary incontinence (OSUI) prior to surgical intervention for pelvic organ prolapse (POP) repair may allow for adding an anti-incontinence procedure and thus prevent postoperative SUI. OBJECTIVES: To compare preoperative detection rates for OSUI by either a multichannel urodynamic investigation or by a plain pelvic examination. METHODS: We retrospectively evaluated the medical charts of all women who underwent urodynamic investigation prior to surgical repair of advanced POP at our institution between 1 January 2006 and 31 December 2012. RESULTS: In total, 720 women underwent surgical POP repair during the study period, of whom 54 (7.5%) were diagnosed with OSUI preoperatively. Of these patients, 54 (100%) were detected by multichannel urodynamic investigation while only 27 (50%) were detected by a plain pelvic examination (P = 0.001). Bladder fullness during the pelvic examination was associated with higher detection rates for OSUI (P = 0.001). Women with OSUI who underwent concomitant tension-free vaginal tape and POP repair procedures did not develop de novo SUI or obstructive voiding symptoms (OVS) postoperatively. CONCLUSIONS: Preoperative multichannel urodynamic investigation has significantly higher detection rates for OSUI than a plain pelvic examination. Utilizing this modality resulted in no cases of de novo SUI or OVS postoperatively.


Subject(s)
Pelvic Organ Prolapse , Urinary Incontinence, Stress , Humans , Female , Urinary Incontinence, Stress/diagnosis , Urinary Incontinence, Stress/surgery , Retrospective Studies , Urodynamics , Pelvic Organ Prolapse/diagnosis , Pelvic Organ Prolapse/surgery , Pelvic Organ Prolapse/complications , Urinary Bladder
8.
Isr Med Assoc J ; 25(12): 842-846, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36573781

ABSTRACT

BACKGROUND: Vaginal hysterectomy (VH) and colpocleisis are both used for the treatment of advanced pelvic organ prolapse (POP). OBJECTIVES: To compare short- and long-term outcomes of vaginal hysterectomy vs. colpocleisis for advanced POP. METHODS: Hospital and outpatient charts of patients who underwent VH or colpocleisis at our institution between January 2006 and December 2015 were reviewed. Clinical data were obtained and analyzed. RESULTS: In this study, 188 patients underwent VH and 32 patients underwent colpocleisis. The colpocleisis group was significantly older than the VH group (79.5 ± 4.5 vs. 69 ± 6.1 years respectively, P < 0.0001) and presented with significantly higher co-morbidity rates and a higher degree of POP. Perioperative blood loss was significantly lower (250 ± 7.6 ml vs. 300 ± 115 ml, P < 0.0001) and postoperative hospitalization was significantly shorter (2 ± 2.7 vs. 3 ± 2.2 days, P = 0.015) among the colpocleisis group. None of the patients from the colpocleisis group required an indwelling urethral catheter after discharge, compared to 27.5% of the patients from the VH group (P = 0.001). Total postoperative complication rate was significantly lower among the colpocleisis group (25% vs. 31% P < 0.0001). Objective recurrence of POP was significantly more common among the VH group (7% vs. 0% and 21% vs. 0% for the anterior and posterior compartments, respectively, P = 0.04). CONCLUSIONS: Colpocleisis is associated with faster recovery, lower perioperative morbidity, and higher success rates than VH and should be considered for frail and elderly patients.


Subject(s)
Hysterectomy, Vaginal , Pelvic Organ Prolapse , Female , Humans , Aged , Hysterectomy, Vaginal/adverse effects , Vagina/surgery , Pelvic Organ Prolapse/surgery , Hysterectomy , Gynecologic Surgical Procedures , Treatment Outcome , Retrospective Studies
9.
Harefuah ; 161(6): 342-348, 2022 Jun.
Article in Hebrew | MEDLINE | ID: mdl-35734789

ABSTRACT

INTRODUCTION: Transvaginal repair of advanced pelvic organ prolapse (POP) often involves vaginal hysterectomy (VH) followed by fixation of the vaginal vault to either the sacrospinous or the uterosacral ligaments. To date, only a few studies have compared the results of these two vaginal vault fixation techniques. OBJECTIVES: To compare short and medium-term results and complications of sacrospinous versus high uterosacral ligament fixation of the vaginal vault after vaginal hysterectomy for the treatment of advanced POP. METHODS: This was a retrospective study obtaining data from the medical records of patients who underwent transvaginal repair of advanced POP with a VH in our institution between the years 2006 and 2017. Demographic and clinical characteristics, perioperative complications and medium-term follow-up data were documented for all patients. RESULTS: We identified 118 women who underwent uterosacral and 46 women who underwent sacrospinous vaginal vault fixation. The overall incidence of perioperative complications was significantly lower in the sacrospinous as compared to the uterosacral fixation group (17.8% vs. 39.3%, P = 0.01). Medium term recurrence rates of moderate to severe POP were similar in both groups (33.3% vs. 35.8%). No significant differences were observed between the two groups in the rates of postoperative urinary or gastrointestinal symptoms. CONCLUSIONS: Sacrospinous fixation of the vaginal vault after vaginal hysterectomy was found to involve a lower rate of perioperative complications as compared to uterosacral ligament fixation. However, the rates of prolapse recurrence and the incidence of postoperative urinary tract and gastrointestinal symptoms were found to be similar in both groups. DISCUSSION: According to the current study, it is not possible to determine a clear superiority for one method of vaginal vault fixation over the other. Both surgical techniques are acceptable, involve reasonable success rates and relatively low postoperative complication rates.


Subject(s)
Hysterectomy, Vaginal , Pelvic Organ Prolapse , Female , Gynecologic Surgical Procedures/adverse effects , Gynecologic Surgical Procedures/methods , Humans , Hysterectomy, Vaginal/adverse effects , Ligaments/surgery , Pelvic Organ Prolapse/surgery , Retrospective Studies , Treatment Outcome
10.
Isr Med Assoc J ; 23(6): 336-340, 2021 Jun.
Article in English | MEDLINE | ID: mdl-34155843

ABSTRACT

BACKGROUND: The novel coronavirus disease 2019 (COVID-19) is an infectious disease that presents an urgent challenge to global health and economy. OBJECTIVES: To assess the effects of population median age and mean ambient temperature on the COVID-19 global pandemic burden. METHODS: We used databases from open access public domains to record population median age, mean ambient temperature, and the numbers of COVID-19 cases and deaths on days 14 and 28 from the pandemic outbreak for each country in the world. We then calculated the correlation between these parameters. RESULTS: The analysis included 202 countries. A univariate analysis showed that population median age significantly correlated with the cumulative number of cases and deaths, while mean ambient temperature showed a significant inverse correlation with the cumulative number of deaths on days 14 and 28 from the epidemic outbreak. After a multivariate logistic regression analysis only population median age retained its statistically significant correlation. CONCLUSIONS: Country population median age significantly correlated with COVID-19 pandemic burden while mean ambient temperature shows a significant inverse correlation only in univariate analysis. Countries with older populations encountered a heavier burden from the COVID-19 pandemic. This information may be valuable for health systems in planning strategies for combating this global health hazard.


Subject(s)
Age Factors , COVID-19 , Climate , Global Health/statistics & numerical data , Public Health , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19/transmission , Communicable Disease Control/methods , Communicable Disease Control/statistics & numerical data , Global Burden of Disease , Humans , Mortality , Public Health/methods , Public Health/statistics & numerical data , SARS-CoV-2 , Temperature
11.
Int Urogynecol J ; 31(5): 933-937, 2020 05.
Article in English | MEDLINE | ID: mdl-31165217

ABSTRACT

INTRODUCTION AND HYPOTHESIS: To determine the prevalence of somatic and psychological triggers for bladder storage symptoms among men and women who have not been diagnosed with overactive bladder (OAB) and to determine their impact on individuals' quality of life (QoL). METHODS: Randomly selected male and female volunteers were screened for the presence of bladder storage symptoms and their impact on their QoL using the UDI-6 and IIQ-7 questionnaires. They were also asked about somatic and psychological triggers for these symptoms using the validated SOPSETO questionnaire. Individuals who had previously been diagnosed with or treated for OAB, prostatic hypertrophy, neurological disease or cancer were excluded. RESULTS: Sixty-six women and 40 men were included. There was a significantly higher prevalence of urinary urgency (41% vs. 19%, p = 0.021), urge urinary incontinence (22% vs. 0%, p = 0.002) and stress urinary incontinence (30% vs. 3%, p = 0.001) among women than men. Total UDI-6 (17± 15 vs. 9± 8, p = 0.04) and IIQ-7 (21± 10 vs. 15± 4, p = 0.02) scores were also higher among women than men. Of the total 34 triggers evaluated, 18 were ranked significantly higher among women than among men. There was a good correlation between the SOPSETO and the UDI-6 and IIQ-7 scores primarily in women (r = 0.46, p < 0.0001; r = 0.69, p < 0.0001) but also in men (r = 0.44, p = 0.009; r = 0.39, p = 0.02). CONCLUSIONS: Women who have not been diagnosed with OAB report bladder storage symptoms more frequently than men. Somatic and psychological triggers are more likely to stimulate these symptoms in women than in men and might add burden to their QoL.


Subject(s)
Quality of Life , Urinary Bladder, Overactive , Female , Humans , Male , Surveys and Questionnaires , Urinary Bladder, Overactive/epidemiology , Urinary Bladder, Overactive/etiology , Urinary Incontinence, Urge
12.
Eur J Obstet Gynecol Reprod Biol ; 242: 12-16, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31525694

ABSTRACT

OBJECTIVES: To characterize obstructive voiding symptoms (OVS) in patients with overactive bladder (OAB) and normal postvoid residual volume (PVR) and assess their impact on patients' quality of life (QoL) and sexual function. STUDY DESIGN: Patients with OAB and normal PVR who visited our urogynecologic clinic between November 2016 and June 2017 were asked to fill a questionnaire comprising of 14 statements regarding Obstructive VOiding Symptoms (the OVOS questionnaire). Patients additionaly completed the UDI-6 and IIQ-7 questionnaires. Statistical analysis was performed to determine the prevalence of each OVS and its correlation with the UDI-6 and IIQ-7 scores. RESULTS: Thirty-eight women enrolled in this study. The OVOS questionnaire was found to have good reliability (Cronbach's alpha = 0.75) and construct validity. Thirty-six (95%) women reported having at least one, while 34 (90%) had at least two, and 31 (82%) had at least three OVS. The statement: `I feel that I am unable to empty my bladder completely` significantly correlated with the sense of frustration (r = 0.44, p = 0.006), as well as with the overall negative impact of urinary incontinence on QoL (r = 0.36, p = 0.03). The statement: `I feel a sensation of fullness immediately after I empty my bladder` significantly correlated with the total impact of urinary incontinence on sexual function (r = 0.42, p = 0.031). CONCLUSIONS: Most patients with OAB and normal PVR complain of OVS which may increase the burden on their QoL and sexual function. Some OVS correlate with various segments of the UDI-6 and IIQ-7 questionnaires, suggesting that storage and OVS may share common pathophysiological mechanisms.


Subject(s)
Urethral Obstruction/complications , Urinary Bladder, Overactive/physiopathology , Aged , Female , Humans , Middle Aged , Prospective Studies , Urinary Bladder, Overactive/complications
13.
PLoS One ; 14(4): e0214840, 2019.
Article in English | MEDLINE | ID: mdl-30947286

ABSTRACT

OBJECTIVE: Studies have demonstrated an association between ABO blood type and bleeding status. The aim of this analysis was to determine whether O blood type is associated with higher early postpartum hemorrhage (PPH) risk as compared to other blood types. STUDY DESIGN: In this retrospective case-control study, data was gathered form 4,516 deliveries occurring at our institution between 2014 and 2016. Cases were categorized into one of two groups according to women's major blood type (O or non-O), and thereafter according to minor blood type (RH positive or negative). The primary outcome was early PPH which was further stratified by clinical severity according to the decrement in hemoglobin concentration after delivery. Categorical variables were compared using the χ2 test while continuous variables were compared using the student's t-test. All data were further analyzed using a stepwise logistic regression model. RESULTS: 1,594 (35.3%) of 4,516 women included in this analysis had O blood type. Early PPH occurred in 44 women (2.7%) with O blood type and 65 women (2.22%) with other blood types. O blood type was not associated with an increased risk for early PPH (OR 1.24, 95% CI 0.84-1.82, P = 0.275). This lack of association remained unchanged after stratification by PPH severity. There was also no significant association between Rh blood type and the risk for early PPH (OR 0.97, 95% CI 0.44-1.4, P = 0.422). CONCLUSIONS: In this cohort, O blood type was not associated with an increased risk for early PPH.


Subject(s)
Blood Group Antigens , Postpartum Hemorrhage/blood , Postpartum Hemorrhage/etiology , ABO Blood-Group System , Adult , Case-Control Studies , Cohort Studies , Female , Humans , Israel , Logistic Models , Middle Aged , Pregnancy , Rh-Hr Blood-Group System , Risk Factors , Young Adult
14.
Neurourol Urodyn ; 37(1): 163-168, 2018 01.
Article in English | MEDLINE | ID: mdl-28220549

ABSTRACT

AIMS: Patients with overactive bladder (OAB) often describe somatic, psychological, and sexual triggers for their symptoms. The aim of this study was to characterize these triggers and assess their impact on patients' symptoms and quality of life (QoL). METHODS: Patients who visited our urogynecologic clinic between August 2015 and March 2016 and diagnosed with OAB syndrome were asked to fill a questionnaire comprising 34 statements regarding SOmatic, Psychological, and Sexual Triggers for OAB (SOPSETO). Patients additionaly completed the UDI-6 and IIQ-7 questionnaires. Statistical analysis was performed to determine the prevalence of each trigger and its correlation with the UDI-6 and IIQ-7 scores. RESULTS: Sixty four women enrolled in this study. The SOPSETO questionnaire was found to be relaiable with Cronbach's alpha of 0.73-0.88. Construct validity was high with good correlation between the SOPSETO and the UDI-6 and IIQ-7 questionnaires. The triggers which had the highest correlation with the total UDI-6 scores were: Being far from toilets (r = 0.32, P = 0.004), swimming (r = 0.44, P = 0.02), taking a shower/bath (r = 0.36, P = 0.004), touching water (r = 0.35, P = 0.004), stepping out of a car (r = 0.32, P = 0.014), and experiencing an orgasm (r = 0.59, P = 0.001). The triggers: Experiencing an orgasm (r = 0.4, P = 0.033), having intercourse (r = 0.53, P = 0.002), stepping out of a car (r = 0.45, P = 0.001), and touching water (r = 0.28, P = 0.03) most significantly correlated with the total IIQ-7 scores. CONCLUSIONS: Certain somatic, psychological, and sexual factors may trigger OAB symptoms and are therefore potential targets for behavioral therapy of this disorder, and for further research regarding its pathophysiological mechanisms.


Subject(s)
Quality of Life/psychology , Sexual Behavior/psychology , Urinary Bladder, Overactive/epidemiology , Urinary Bladder, Overactive/psychology , Aged , Female , Humans , Middle Aged , Orgasm , Prevalence , Surveys and Questionnaires , Swimming
15.
Taiwan J Obstet Gynecol ; 56(6): 750-754, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29241914

ABSTRACT

OBJECTIVE: Laminin is a connective tissue component. The LAMC1 gene encodes for gamma-1 chain of laminin, which is associated with familial clustering of POP. The ERα gene which encodes for cellular estrogen receptor has also been associated with POP. The aim of this study was to evaluate a possible correlation between polymorphism in these genes and the risk for developing POP. MATERIALS AND METHODS: Blood samples were drawn from 33 women with advanced POP (study group) and 33 women without POP (control group). DNA was extracted, and the presence of the rs10911193 C/T mutation in LAMC1 and of the rs2228480 G/A mutation in ERα was detected using the PCR technique. RESULTS: 26 samples were available for each group regarding ERα. 33 samples were available for each group, regarding LAMC1. The prevalence of homozygotes for the ERα rs2228480 G/A mutation was 19.2% and 0% among women with and without POP, respectively (OR 39.77, 95% CI 1.93-817.0, P = 0.00046). The prevalence of heterozygotes for this mutation was 83.3% and 11.5%, respectively (OR 19.2, 95% CI 4.15-88.6, P < 0.0001). The prevalence of homozygotes for the LAMC1 gene rs10911193 C/T mutation was 3.6% and 6.1% among women with and without POP (NS), while the respective for heterozygotes for this mutation was 21.4% and 33.3% (NS). CONCLUSIONS: Polymorphism in the ERα gene is associated with an increased risk for advanced POP. However, polymorphism in the LAMC1 gene does not seem to be associated with such risk.


Subject(s)
Estrogen Receptor alpha/blood , Laminin/blood , Pelvic Organ Prolapse/genetics , Polymorphism, Genetic , Case-Control Studies , Female , Genetic Heterogeneity , Homozygote , Humans , Middle Aged , Prospective Studies , Risk Factors
16.
Int Urogynecol J ; 28(1): 101-104, 2017 Jan.
Article in English | MEDLINE | ID: mdl-27372946

ABSTRACT

INTRODUCTION AND HYPOTHESIS: Laparoscopic sacral colpopexy (SC) is increasingly utilized in the surgical management of apical prolapse. It involves attachment of a synthetic mesh to the sacral promontory and to the prolapsed vaginal walls. The median sacral artery (MSA) runs close to the site of mesh attachment and is therefore prone to intraoperative injury, which may lead to profound hemorrhaging. The aim of this study was to determine the location of the MSA at the level of the sacral promontory with regard to adjacent visible anatomical landmarks. Surgeons may use this information to reduce the risk for presacral bleeding. METHODS: Sixty consecutive contrast-enhanced pelvic computed tomography scans were revised, and the location of the MSA at the level of the sacral promontory was determined in relation to the ureters, iliac arteries, sacral midline, and aortic bifurcation. RESULTS: The MSA runs 0.2 ± 3.9 mm left to the midline of the sacral promontory and 48.0 ± 15.4 mm caudal to the aortic bifurcation. The ureters, internal and external iliac arteries on the right were significantly closer to the MSA than on the left (30.0 ± 7.1 vs 35.2 ± 8.8 mm, p = 0.001; 21.5 ± 6.8 vs 30.3 ± 8.4 mm, p < 0.0001; 32.8 ± 10.2 vs 41.9 ± 14.5 mm, p = 0.005 respectively). CONCLUSIONS: The MSA, which runs left to the midline of the sacral promontory, and its location can be determined intraoperatively in relation to adjacent visible anatomical structures. The iliac vessels and ureter on the right are significantly closer to the MSA than those on the left. This information may help surgeons performing SC to avoid MSA injury, thus reducing operative morbidity.


Subject(s)
Arteries/diagnostic imaging , Multidetector Computed Tomography/methods , Sacrum/diagnostic imaging , Uterine Prolapse/diagnostic imaging , Aged , Aorta, Abdominal/diagnostic imaging , Aorta, Abdominal/pathology , Arteries/pathology , Arteries/surgery , Colposcopy/methods , Contrast Media/administration & dosage , Female , Humans , Iliac Artery/diagnostic imaging , Iliac Artery/pathology , Iohexol/administration & dosage , Laparoscopy/methods , Middle Aged , Sacrum/blood supply , Sacrum/surgery , Surgical Mesh , Ureter/blood supply , Ureter/diagnostic imaging , Uterine Prolapse/pathology , Uterine Prolapse/surgery
17.
Int Urogynecol J ; 28(2): 191-213, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27921161

ABSTRACT

INTRODUCTION AND HYPOTHESIS: There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus report. METHODS: This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper. RESULTS: A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible. CONCLUSION: A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research.


Subject(s)
Conservative Treatment/methods , Gynecology/standards , Pelvic Floor Disorders/therapy , Terminology as Topic , Urology/standards , Diagnostic Imaging/methods , Female , Gynecological Examination/methods , Humans , Pelvic Floor/physiopathology , Pelvic Pain/diagnosis , Pelvic Pain/therapy , Societies, Medical , Urinary Incontinence/diagnosis , Urinary Incontinence/therapy , Urodynamics/physiology
18.
Neurourol Urodyn ; 36(2): 221-244, 2017 02.
Article in English | MEDLINE | ID: mdl-27918122

ABSTRACT

Introduction and hypothesis There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus report. Methods This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper. Results A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible. Conclusion A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research.


Subject(s)
Conservative Treatment/methods , Pelvic Floor Disorders/therapy , Terminology as Topic , Female , Humans , Pelvic Floor Disorders/diagnosis , Societies, Medical , Symptom Assessment , Urology/standards
19.
Eur J Obstet Gynecol Reprod Biol ; 206: 194-197, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27723550

ABSTRACT

OBJECTIVES: Infected pelvic hematoma is a relatively common complication of vaginal hysterectomy, manifesting with postoperative pain and fever which often necessitate surgical drainage. We aimed to assess the effect of the surgical technique for vaginal cuff closure on the incidence of this complication. STUDY DESIGN: Until March 31, 2010, our surgical protocol for vaginal hysterectomy included complete vaginal cuff closure. After this date, all surgeries were performed using another technique, by which a patent tract was left at the vaginal cuff for drainage of blood, secretions and debris. We reviewed medical records of all women who underwent vaginal hysterectomy for pelvic organ prolapse in our institution between January 2006 and November 2015, including demographic, clinical and surgical data. We compared the incidence of postoperative infected pelvic hematomas before and after March 31, 2010. RESULTS: We identified 325 women who underwent vaginal hysterectomy during the first time period (group I) and 243 women who underwent this procedure during the second time period (group II). While demographic and clinical data were not significantly different between the two groups, the incidence of infected pelvic hematomas necessitating hospitalization was significantly lower in group II (3.8% vs. 13.5%, p<0.0001). CONCLUSIONS: A significant reduction in the incidence of infected pelvic hematoma following vaginal hysterectomy was noted using a surgical technique that allows for drainage of blood and debris through the vaginal cuff.


Subject(s)
Genital Diseases, Female/etiology , Hematoma/etiology , Hysterectomy, Vaginal/methods , Pelvic Organ Prolapse/surgery , Wound Closure Techniques/adverse effects , Aged , Female , Humans , Hysterectomy, Vaginal/adverse effects , Middle Aged , Pelvis/surgery , Risk Factors
20.
Int Urogynecol J ; 27(12): 1925-1927, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27423455

ABSTRACT

INTRODUCTION AND HYPOTHESIS: Urethrovaginal fistula is a rare disorder that may occur following sling procedures for stress urinary incontinence, excision of a urethral diverticulum, anterior vaginal wall repair, radiation therapy, and prolonged indwelling urethral catheter. The most common clinical manifestation is continuous urinary leakage through the vagina, aggravated by an increase in the intra-abdominal pressure. Appropriate management, including timing of the surgical intervention and the preferred technique, remains controversial. METHODS: This video presentation describes the transvaginal repair of a urethrovaginal fistula using the Latzko technique and a bulbocavernosus (Martius) flap. RESULTS: The patient's postoperative course was uneventful. At her follow-up visit 2 months later, she was free of urinary leakage, and a pelvic examination revealed excellent healing, with complete closure of the fistula. CONCLUSIONS: Transvaginal repair using the Latzko technique with a vascular bulbocavernosus (Martius) flap is an effective and safe mode of treatment.


Subject(s)
Gynecologic Surgical Procedures/methods , Urethral Diseases/surgery , Vaginal Fistula/surgery , Female , Humans , Middle Aged , Surgical Flaps
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