Lymphocytosis in children after the Chornobyl NPP accident.

OBJECTIVE: To establish the sources of lymphocytosis in children living in ecologically unfavorable conditions after the Chornobyl Nuclear Power Plant accident aiming the high risk group formation for oncohematological diseases among the children's population. MATERIALS AND METHODS: The 226 children with lymphocytosis were surveyed. The of child's life history and kind of somatic morbidity were considered. Quantitative and qualitative parameters of blood cells, biochemical indices including immunoglobulins (A, M, G), circulating immune complexes, phagocytosis indices were assayed. RESULTS: Children with lymphocytosis were more often born with a high bodyweight, they demonstrated manifestations of constitutional lymphatism, lymphadenopathy and more often had respiratory infections. Quantitative and qualitative changes of hemopoietic elements depended on a type of a disease. Activation of lipid peroxidation, dysimmunoglobulinemia and increased level of circulating immune complexes were revealed. Treatment and preventive actions promoted normalization of hemogram indices in 58% of children surveyed. CONCLUSIONS: The abnormalities in immune indices, activated lipid peroxidation in membranes of hemopoietic elements, and manifestations of granulocytopoietic disorders were established it children with lymphocytosis. Therefore these children can be attributed tot the group of increased risk on oncohematological disease.

Congenital malformations of the urinary system in children born to exposed parents according to Congenital and Hereditary Diseases Department data.

OBJECTIVE: To analyze the frequency and structure of the urinary system malformations in children born to parents exposed to radiation. MATERIAL AND METHODS: The study included 1,139 children with various congenital malformations of the urinary system, which were examined and treated in the Department of Congenital and Hereditary Diseases from 2000 to 2011. The standard clinical, laboratory, instrumental and radiographic methods were applied to verify the diagnosis. RESULTS AND CONCLUSIONS: 1. The proportion of children with congenital malformations of the urinary system among all examined in the Department of Congenital and Hereditary Diseases in the 12 years was 68.24%. 2. The congenital malformations accounted for 31.16%, small anomalies for 68.31%, and their combinations for 4.57% among all malformations of the urinary system. 3. Such complications as a secondary pyelonephritis occurred in 4.39% of cases and developed mainly in children with obstructive uropathy.