ABSTRACT
BACKGROUND: The present study aims to estimate the possible relationship between periodontal pathogens in the oral cavity and the birth of Preterm Birth (PTB) and/or Low Birth Weight (LBW). MATERIAL AND METHODS: It's a case- control study with the subgengival biofilm samples were collected from four sites up deeper until 48 hours postpartum and were processes by Polymerase Chain Reaction (PCR) for presence the periodontal pathogens Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg), Treponema denticola (Td), Tannerella forsythia (Tf) e Aggregatibacter actinomycetemcomitans (Aa). The mothers were divided into case grup (babies weighing < 2500 g and/or gestational age < 37 weeks) and control group (babies weighing ≥ 2500 g and gestational age ≥ 37 weeks). Chi-square test and the measure of association obtained by Odds Ratio (OR) were used to estimate the association between the variables. RESULTS: Microbial analyses results showed no significant association between PTB and LBW with most periodontal pathogens in the oral cavity, even with association with the clinical presence of periodontitis. CONCLUSIONS: given the high presence of periodontal pathogens in the biofilm subgengival of recent mothers, it is suggested that the findings of this research serve as the basis for future studies on the pathophysiology involved in the relationship between periodontitis and PTB and/or LBW
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Subject(s)
Humans , Female , Pregnancy , Infant, Newborn , Child , Adolescent , Young Adult , Adult , Periodontal Diseases/microbiology , Infant, Very Low Birth Weight , Premature Birth , Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis/isolation & purification , Prevotella intermedia/isolation & purification , Treponema denticola/isolation & purification , Case-Control Studies , Polymerase Chain ReactionABSTRACT
Introduction: Metabolic syndrome (MS) is a complex pathology that combines several risk factors for cardiovascular disease. It is defined by the presence of visceral obesity, elevated triglycerides, decreased HDL, elevated blood pressure and blood glucose. The presence of at least three of these factors characterizes the syndrome. Periodontal disease (PD) is a chronic infection that produces a local and systemic inflammatory response. PD has been suggested as a possible risk factor for some of the components of MS, such as diabetes, obesity and dyslipidemia. Objective: The aim of this study was to review the literature about the possible association between periodontal disease and metabolic syndrome and to identify the components of this syndrome that may contribute to this association. Literature review: PD in the body produces a subclinical inflammatory state characterized by the release of inflammatory cytokines. Conclusion: It is plausible that these substances may contribute to the development of metabolic syndrome.
