ABSTRACT
Gastrointestinal (GI) diseases, such as inflammatory bowel diseases (IBD), can manifest themselves with intestinal and extra-intestinal symptoms. Among the latter, cutaneous manifestations, such as pyoderma gangraenosum (PG) and metastatic Crohn's disease (MCD), represent a possible onset of IBD, with or without simultaneous bowel alterations. In such cases, intestinal and skin lesions are supported by the same immune-mediated mechanism. We hereby report two cases of patients with skin manifestations together with signs and symptoms suggestive of IBD. IBD and some skin lesions arise from the same immune-mediated mechanism. A multidisciplinary approach to these immune-mediated diseases is needed for an early and correct diagnosis, which in turn may lead to the use of the right drug avoiding useless treatment.
Subject(s)
Inflammatory Bowel Diseases/diagnosis , Skin Diseases/etiology , Adult , Crohn Disease/complications , Crohn Disease/diagnosis , Female , Humans , Inflammatory Bowel Diseases/complications , Middle Aged , Pyoderma Gangrenosum/etiologySubject(s)
Dermatitis/psychology , Self-Injurious Behavior/psychology , Self-Injurious Behavior/therapy , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/therapeutic use , Dermatitis/drug therapy , Dermatitis/etiology , Female , Histamine Antagonists/administration & dosage , Histamine Antagonists/therapeutic use , Humans , Male , Mental Disorders , Middle Aged , Naloxone/therapeutic use , Pruritus/psychologySubject(s)
Tinea Versicolor/diagnosis , Adolescent , Antifungal Agents/therapeutic use , Forearm/microbiology , Humans , Itraconazole/therapeutic use , Knee/microbiology , Malassezia/isolation & purification , Male , Tinea Versicolor/drug therapy , Tinea Versicolor/microbiology , Tinea Versicolor/pathologyABSTRACT
Serratia marcescens is a species of gram negative bacillus, classified as a member of the Enterobacteriaceae, mainly involved in opportunistic infections, particulary in the hospital environment. Cutaneous infections have rarely reported in literature and are predominantly observed in elderly or in immunocompromised patients. The clinical manifestations of skin infections include granulomatous lesions, necrotizing fasciitis, nodules, cellulitis, ulcers, dermal abscesses. Infections caused by S. marcescens may be difficult to treat because of resistance to a variety of antibiotics, including ampicillin and first and second generation cephalosporins. Aminoglycosides have good activity against S. marcescens, but resistant strains have also been described. We report a very intriguing case of S. marcescens infection, in an immunocompetent 18-year-old man, causing multiple rounded ulcers of varying sizes, along with few pustular lesions that both clinically and histopathologically mimic a pyoderma gangrenosum (PG). This is a non infectious neutrophilic skin disorder, characterized by painful and rapidly progressing skin ulceration. According to our experience, we would strongly recommend to perform cultures of multiple skin ulcers resembling PG, even in young healthy patients, to ensure correct diagnosis and treatment, since resistant to conventional antibiotics bacteria such as S. marcescens may be the cause of these lesions, like in the case here reported.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Ciprofloxacin/therapeutic use , Immunocompetence , Serratia Infections/diagnosis , Serratia Infections/drug therapy , Serratia marcescens/isolation & purification , Skin Ulcer/drug therapy , Skin Ulcer/microbiology , Adolescent , Diagnosis, Differential , Humans , Male , Pyoderma Gangrenosum/diagnosis , Serratia Infections/complications , Skin Ulcer/diagnosis , Treatment OutcomeABSTRACT
Magnesium stearate is a substance often used as a diluent in the manufacture of medical tablets, capsules and powders. Moreover it is usually found as a food additive or pharmaceutical excipient. We report the first case of a 28 years old woman affected by an allergic reaction from this substance with an urticarial manifestation.
Subject(s)
Allergens/immunology , Stearic Acids/immunology , Urticaria/etiology , Adult , Female , HumansABSTRACT
Airborne contact dermatitis is a dermatological disease manifesting predominantly on the face, neck and arms, which is caused by volatile substances which settle on exposed skin. Although the diagnosis is not difficult, the finding of causative allergens and the exclusion of differential diagnoses are still lacking by the treating dermatologists.
Subject(s)
Antigens, Plant/immunology , Cupressus/immunology , Dermatitis, Allergic Contact/immunology , Dermatitis, Perioral/immunology , Aged , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/drug therapy , Dermatitis, Perioral/diagnosis , Dermatitis, Perioral/drug therapy , Environmental Exposure , Female , Histamine Antagonists/therapeutic use , Humans , Intradermal Tests , Predictive Value of Tests , Steroids/therapeutic use , Treatment OutcomeABSTRACT
Anti-TNF drugs may be associated with various adverse reactions including cutaneous ones. We describe the case of a 45-year-old woman affected by undifferentiated spondyloarthritis who presented a localized psoriasiformis dermatitis during treatment with adalimumab, without any medical history of psoriasis.
Subject(s)
Anti-Inflammatory Agents/adverse effects , Antibodies, Monoclonal, Humanized/adverse effects , Drug Eruptions/etiology , Psoriasis/chemically induced , Skin/drug effects , Spondylarthropathies/drug therapy , Adalimumab , Biopsy , Drug Eruptions/pathology , Female , Humans , Middle Aged , Psoriasis/pathology , Skin/pathology , Spondylarthropathies/immunology , Tumor Necrosis Factor-alpha/antagonists & inhibitorsABSTRACT
Nickel deficiency leads to reduced iron content in organs and to reduced hemoglobin levels and haematocrit counts. We carried out a clinical trial of oral hyposensitization therapy with low doses of nickel on a group of 20 patients affected by systemic allergy to this sensitizer element and with a chronic relapsing low hemoglobin level and haematocrit count. We obtained interesting results on maintaining these values in treated patients.
Subject(s)
Desensitization, Immunologic , Hematocrit , Hemoglobins/metabolism , Hypersensitivity/therapy , Nickel/administration & dosage , Nickel/immunology , Administration, Oral , Biomarkers/blood , Desensitization, Immunologic/adverse effects , Humans , Hypersensitivity/blood , Hypersensitivity/diagnosis , Hypersensitivity/immunology , Maryland , Nickel/adverse effects , Patch Tests , Time Factors , Treatment OutcomeABSTRACT
In Western countries the phenomenon of "tattooing" is expanding and tattoos are considered a new fashion among young people. In this paper we briefly trace the history of tattooing, the techniques used, the analysis of pigments used, and their possible adverse reactions. We also carried out a review of the international literature on the use of Q-switched laser in tattoo removal and its complications, and we describe our experience in the use of this technique.
Subject(s)
Ink , Laser Therapy/instrumentation , Lasers, Solid-State , Tattooing , History, 20th Century , History, 21st Century , Humans , Laser Therapy/adverse effects , Laser Therapy/history , Lasers, Solid-State/adverse effects , Lasers, Solid-State/history , Male , Tattooing/history , Time Factors , Treatment OutcomeABSTRACT
Pemphigus herpetiformis is a rare clinical entity belonging to the group of autoimmune blistering disorders of the skin, that usually presents clinical features of dermatitis herpetiformis and immunologically findings of pemphigus. Because of the variety of its presentation, differential diagnosis with other bollous diseases is not simple and histopathological results have to be supported by direct immunofluorescence assay, for a correct diagnosis. We report the case of a young woman, where immunofluorescence was a fundamental tool to reach the diagnosis of pemphigus herpetiformis, because of the lack of acantholitic cells at histological sample.
Subject(s)
Pemphigus/diagnosis , Abdomen , Acantholysis , Adult , Anti-Inflammatory Agents/therapeutic use , Axilla , Dermatitis Herpetiformis/diagnosis , Diagnosis, Differential , Eosinophilia/diagnosis , Eosinophilia/etiology , Female , Fluorescent Antibody Technique, Direct , Groin , Humans , Immunosuppressive Agents/therapeutic use , Leg , Pemphigus/classification , Pemphigus/drug therapy , Pemphigus/pathology , Prednisone/therapeutic use , Pregnenediones/therapeutic useABSTRACT
An association between psoriasis and cardiovascular diseases has been reported, and treatment of this condition is often considered difficult because the conventional systemic therapies often show several side effects. To assess the efficacy and tolerability of a new drug, folinate calcium, to treat psoriasis, a total of 58 patients affected by active psoriasis were enrolled in a variable period study. These patients had clinically stable, plaque psoriasis involving greater than or equal 6% body surface area. Thirty of these patients were treated with folinate calcium therapy, 15 mg orally once daily, for a variable period based on each patients clinical response. The comparison was made with 28 psoriatic patients treated with conventional systemic therapies (cyclosporine, acitretin, etanercept, efalizumab, infliximab, adalimumab). A clinical improvement was observed in both group, but in the first one we did not observe any side effects, whereas some important side effects were observed in the second. These preliminary results support the effectiveness and tolerability of folinate calcium treatment in psoriasis.
