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Chemistry of pseudomonic acid. Part 16. Aryl and heteroaryl ketone derivatives of monic acid.

Abson, A; Broom, N J; Coates, P A; Elder, J S; Forrest, A K; Hannan, P C; Hicks, A J; O'Hanlon, P J; Masson, N D; Pearson, N D; Pons, J E; Wilson, J M.

J Antibiot (Tokyo) ; 49(4): 390-4, 1996 Apr.

Article in English | MEDLINE | ID: mdl-8642004

ABSTRACT

The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.

Subject(s)

Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Mupirocin/analogs & derivatives , Mupirocin/chemistry , Animals , Anti-Bacterial Agents/pharmacokinetics , Humans , Ketones/chemistry , Male , Mice , Mice, Inbred Strains , Microbial Sensitivity Tests , Mupirocin/pharmacology , Sepsis/drug therapy , Staphylococcal Infections/drug therapy , Structure-Activity Relationship , Thiazoles/chemistry

ABSTRACT

Subject(s)

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