ABSTRACT
To evaluate the effectiveness of hepatitis B virus (HBV) vaccination of household contacts of HBV carriers in Tulkarm district, Palestine, quantitative hepatitis B surface (anti-HBs) antibody response in 161 household contacts was measured after vaccination. A seroprotective anti-HBs response (titre > or = 10 IU/L) was elicited in all vaccinated subjects. Of these 2.5% had titres of 10-99 IU/L, 61.5% 100-999 IU/L and 36.0% > or = 1000 IU/L. The number of vaccination doses had no effect on the achievement of seroprotection. HBV infection was demonstrated in 13 cases and their anti-HBV titres were in the range 25-350 IU/L.
Subject(s)
Carrier State/prevention & control , Family Characteristics , Hepatitis B Antibodies/blood , Hepatitis B Vaccines/immunology , Hepatitis B/prevention & control , Immunization Programs/organization & administration , Mandatory Programs/organization & administration , Vaccination/methods , Vaccination/statistics & numerical data , Adolescent , Adult , Carrier State/epidemiology , Carrier State/immunology , Child , Child, Preschool , Contact Tracing , Endemic Diseases/prevention & control , Endemic Diseases/statistics & numerical data , Female , Hepatitis B/epidemiology , Hepatitis B/immunology , Humans , Immunization Schedule , Male , Middle Aged , Middle East/epidemiology , Patient Selection , Program Evaluation , Risk Factors , Seroepidemiologic StudiesABSTRACT
To evaluate the effectiveness of hepatitis B virus [HBV] vaccination of household contacts of HBV carriers in Tulkarm district, Palestine, quantitative hepatitis B surface [anti-HBs] antibody response in 161 household contacts was measured after vaccination. A seroprotective anti-HBs response [titre > or = 10 IU/L] was elicited in all vaccinated subjects. Of these 2.5% had titres of 10-99 IU/L, 61.5% 100-999 IU/L and 36.0% > or = 1000 IU/L.The number of vaccination doses had no effect on the achievement of seroprotection. HBV infection was demonstrated in 13 cases and their anti-HBV titres were in the range 25-350 IU/L
