Pulmonary Langerhans Cell Histiocytosis Post-Hodgkin Lymphoma Completely Resolved With Vinblastine in a Heavy Smoker: Coincidence or Causation?

The association among Langerhans cell histiocytosis, hematolymphoid malignancies, and heavy smoking has been addressed in medical literature to identify a possible potential link. Such occurrence can pose diagnostic challenges, as well as important clinical implications for disease progression and treatment approaches. We present pulmonary Langerhans cell histiocytosis instance in a 35-year-old male patient, with a 34-pack-year smoking history and nodular sclerosing Hodgkin lymphoma stage IIB who developed multiple bilateral lung nodules. The patient completed 6 cycles of doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine chemotherapy and radiotherapy 2 years earlier. CT chest scans revealed numerous micronodules scattered randomly throughout the upper and lower left lung lobes. Subsequent wedge resection exhibited cellular proliferation with grooved nuclei, eosinophilic cytoplasm, and surrounding inflammatory components. Immunohistochemical staining showed positive staining for S100 and CD1a confirming a diagnosis of pulmonary Langerhans cell histiocytosis. The patient responded to a 6-week treatment with vinblastine and prednisolone. A subsequent CT scan of the lungs revealed complete resolution after 3 years. This report underscores the importance of identifying pulmonary Langerhans cell histiocytosis in heavy smokers with Hodgkin lymphoma presenting with multiple nodular pulmonary lesions. For patients with Hodgkin lymphoma and a possible genetic predisposition, smoking may contribute to the overt development of pulmonary Langerhans cell histiocytosis. Therefore, smoking cessation and careful follow-up examinations are required. Further research is recommended to elucidate the underlying mechanisms of this intriguing association.

Non-Hodgkin's lymphoma relapse as Burkitt lymphoma leading to ileocecal intussusception in an adult patient-a case report.

Burkitt Lymphoma, an aggressive form of non-Hodgkin's lymphoma, is a rare cause of ileocolic intussusception in adult patients. We present the case of a 17-year-old male patient, with a history of non-Hodgkin's lymphoma in childhood, presenting with acute abdominal pain, vomiting, and diarrhea. CT and colonoscopy findings revealed ileocolic intussusception with a large ileocecal mass, leading to a diagnosis of Burkitt Lymphoma after histopathological and immunohistochemical examination. This case highlights the rarity of Burkitt Lymphoma causing intussusception in adults, a condition more commonly seen in children. The case also underscores the importance of considering Burkitt Lymphoma in patients with a history of non-Hodgkin's lymphoma presenting with acute abdominal symptoms. He was successfully treated with surgery without any complications. On follow-ups, he is doing well.

Lipoprotein Glomerulopathy With Complete Resolution With Fenofibrate: Report of First Case From Pakistan.

Background: Lipoprotein glomerulopathy is an infrequent glomerular disorder that culminates in nephrotic syndrome and often progresses to kidney failure. Whereas most patients have been reported in Japan and China, limited reports have been documented outside these regions. This patient represents the first report of lipoprotein glomerulopathy in Pakistan. Case Presentation: A 25-year-old male patient, hypertensive for 2 years, presented with progressive body edema, frothy urine, and fatigue. Examination revealed elevated blood pressure, bilateral pedal edema, and positive shifting dullness. Laboratory results showed significant proteinuria and elevated cholesterol and triglyceride levels. Renal biopsy revealed enlarged glomeruli with a dilated capillary lumen filled with pale-staining mesh-like material "lipoprotein thrombi." Mild tubular atrophy and interstitial inflammation were observed. No interstitial fibrosis was evident. Electron microscopy detailed the lipoprotein thrombi with lipid granules and vacuoles of various sizes. A diagnosis of lipoprotein glomerulopathy was rendered. Treatment with fenofibrate, rosuvastatin, and captopril led to notable improvements in symptoms, blood pressure, and lipid levels during a 6-month follow-up. Subsequent biopsy showed complete resolution of the lipoprotein thrombi and a significant reduction in subendothelial granular densities. However, the flocculent subendothelial material persisted to some extent despite the complete resolution of lipoprotein thrombi. Conclusion: This report underscores the rarity of lipoprotein glomerulopathy in Pakistan and contributes valuable insights into its histopathologic features and global epidemiology. This unique instance aims to raise awareness among healthcare professionals, aiding in improved recognition of this rare entity. The favorable response to fenofibrate treatment underscores its effectiveness in managing lipoprotein glomerulopathy.

Malignant Para-Testicular Mesothelioma: A Rare Presentation in the Tunica Vaginalis of an Elderly Male With No Prior Asbestos Exposure.

Malignant mesothelioma of the tunica vaginalis is an extremely rare and aggressive tumor that is frequently encountered in elderly patients. The diagnosis of malignant mesothelioma of the tunica vaginalis poses a diagnostic challenge due to its infrequency and nonspecific clinical presentation. Histopathological examination and immunohistochemical staining are essential in differentiating this tumor from other para-testicular masses and establishing a definitive diagnosis. Early detection and comprehensive treatment planning are crucial for improving the prognosis and overall outcomes for patients with this rare malignancy. We present a report of malignant mesothelioma of the tunica vaginalis in a 78-year-old male patient with no history of asbestos exposure who presented with a large infiltrative left para-testicular mass. Histopathological examination revealed a biphasic proliferation composed of epithelioid and spindle cells with infiltrative features, foci of necrosis, and increased mitotic figures. Immunohistochemical staining exhibited positive staining for WT1, D2-40, and calretinin, supporting the mesothelial origin of the tumor. Notably, BerEP4 staining was negative, arguing against carcinoma. Immunostaining for keratin 5 was positive, supporting the mesothelial differentiation. The Ki67 proliferation index was high. The differential diagnosis included adenomatoid tumors, germ cell tumors, and pleomorphic sarcoma. We aim to discuss the clinical presentation, diagnostic approach, and therapeutic approaches of this rare entity.

Superficial CD34-Positive Fibroblastic Tumor: A Newly Recognized Entity With Overlapping Features of PRDM10-Rearranged Soft Tissue Tumors.

Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently identified, infrequent, low-grade mesenchymal neoplasm, first identified in 2014. Although it is relatively new to the field, SCPFT has been gaining prominence in surgical pathology practice because of its distinctive features. As of now, there are limited reported cases of SCPFT, with fewer than 100 instances documented in scientific literature. This distinctive blend of rarity and intriguing variability in presentation emphasizes the significance of identifying and understanding this uncommon entity, facilitating precise diagnosis and optimal management. In this article, we aimed to present a notable case of SCPFT in a male in his 20s who presented with a distinct subcutaneous mass measuring 2.4 × 1.8 cm at the medial aspect of the knee joint. The patient reported no significant medical history or trauma to the affected area. MRI of the knee showed a well-defined 2.4 × 1.8 cm subcutaneous mass with no definite communication with the underlying ligament or meniscus. The histopathological examination revealed spindle cell neoplasm arranged in intersecting fascicles, accompanied by arborizing blood vessels. Neoplastic spindle cells exhibited marked nuclear pleomorphism, and abundant and eosinophilic cytoplasm, with focal areas of granular, glassy, and lipidized cytoplasm. Nuclear pseudo inclusions and a few mitotic figures (1-2 per high-power field) were noted. Inflammatory infiltrates were identified within the neoplasm, comprising eosinophils and lymphocytes, highlighting an immune response within the tumor microenvironment. The surgical margin exhibited involvement with the tumor infiltrates, with the neoplastic cells extending into the adjacent fat tissue. This finding indicates local tumor spread and potential challenges in achieving complete resection. Immunohistochemical staining showed positive staining for CD34, corroborating the diagnosis of a CD34-positive fibroblastic tumor. Focal positive staining for pan-CK was noted. Staining for CD31, smooth muscle actin (SMA), desmin, S100, and anaplastic lymphoma kinase (ALK) was negative, supporting the diagnosis. The Ki67 proliferation index was low.

Great saphenous vein leiomyosarcoma: A case report.

BACKGROUND: Leiomyosarcoma is a type of soft tissue sarcoma and one of the most common subtypes among all sarcomas. It is also the most common malignancy affecting the vascular system with an overall poor prognosis with 10-years survival rate of <60%. Leiomyosarcoma can occur with identifiable risk factors such as radiotherapy exposure or due to unidentifiable factors and genetic factors. CASE: We present a 49-year-old female patient with painful left inner thigh lump for six months which has been increasing in size. The swelling location was in the medial side of the left thigh, non-pulsatile and tender with no signs of hotness, discoloration or discharge. Ultrasound was performed and reported a subcutaneous hypoechoic well-defined lesion that is in close proximity to Great Saphenous Vein. The diagnosis was confirmed after surgical excision and was followed up by computed tomography for metastatic lesions. DISCUSSION: Cases of leiomyosarcoma is rare and usually present with painful swelling. However, non-painful and non-tender lesions can present, and clinicians should be wary of such swelling, especially when they are in close proximity to vascular area. Great saphenous vein leiomyosarcoma is difficult to diagnose solely by radiology, but ultrasound can help guide the course. Other associated factors such as deep venous thrombosis may arise. CONCLUSION: In conclusion, a thorough radiological assessment is necessary in lesions close to vascular lesions to accurately diagnose it.

Prostatic Abscess after Stapled Hemorrhoidopexy Caused by ESBL Extended Spectrum Beta Lactamase Producing Klebsiella pneumoniae: An Additional Challenge to Postoperative Sepsis.

Postoperative septic complications of hemorrhoids surgical interventions are rare, but very serious with high mortality rate. Early diagnosis and prompt therapy are essential to save patient's life. There are a good number of articles and case reports about these septic complications. We are presenting a case report of a prostatic abscess caused by extended spectrum beta lactamase (ESBL) producing Klebsiella pneumoniae after hemorrhoidopexy. Our patient was a healthy middle aged Saudi male who has no significant medical history apart from morbid obesity and recurrent urinary tract infections. ESBL producing K. pneumoniae could be detected only after aspiration of the prostatic abscess, but proper antibiotic was introduced intravenously on admission before culture of aspirate of the abscess was available. Antibiotic was continued for 30 days and abscess resolved completely. In our electronic search, we could not find any case report of prostatic abscess after stapled hemorrhoidopexy caused by ESBL producing organism. This is an additional challenge for treating physicians as these organisms are sensitive only to one group of antibiotics (carbapenem group).

Eosinophilic esophagitis in children from Western saudi arabia: relative frequency, clinical, pathological, endoscopic, and immunological study.

Background and Purpose. Eosinophilic esophagitis (EE) is an evolving allergic disease with an accelerated incidence. The purpose of this study was to delineate the relative frequency and clinicopathological characteristics of EE in children from western Saudi Arabia. Methods. Children with EE were studied retrospectively between October 2002 and December 2011 at King Abdulaziz University Hospital and International Medical Center. Results. The relative frequency of EE was 0.85% of 2127 upper gastrointestinal endoscopies performed during the study period. Eighteen patients were identified with EE. The median age was 8.6 years (range, 1.5-18 years). Thirteen (72.2%) were males. Dysphagia and vomiting were the most common symptoms. Ten (55.6%) children had history of atopy. Testing for food allergy by skin prick test was positive in 11 (61.1%). The most common endoscopic abnormalities were mucosal longitudinal furrow and loss of vascular pattern followed by patchy specks and strictures. The histopathological findings included increased intraepithelial eosinophils, eosinophilic degranulation, lamina propria fibrosis, and eosinophilic microabscesses. Treatment was initiated by swallowed topical corticosteroids in 12 (66.7%) and oral prednisolone in 6 (33%) patients, followed by low dose of topical corticosteroids and dietary elimination. Conclusions. Eosinophilic esophagitis is an uncommon but evolving problem. A high index of suspicion is required for early identifications and intervention to avoid possible complications.