ABSTRACT
The effect of Helicobacter pylori infection on systemic disorders is not well understood. This study was to evaluate the effect of H. pylori eradication on blood count, differential leucocytic count and RBCs indices. In this study, a total of 115 H. pylori positive patients underwent eradication triple therapy for one week, with cured 100 patients. Complete blood count, RBCs indices and differential leucocytic count were analyzed before 2 & 12 weeks after eradication for the cured patients. The results showed that two weeks after H. pylori eradication, platelets count significantly increased but total leucocytic counts and neutrophils were significantly reduced. After three months, RBCs count, Hb concentration, MCV and MCHC were significantly increased, but lymphocytic counts was significantly reduced.
Subject(s)
Clarithromycin/adverse effects , Helicobacter Infections/drug therapy , Helicobacter pylori , Hematologic Diseases/chemically induced , Metronidazole/adverse effects , Omeprazole/adverse effects , Adult , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/therapeutic use , Clarithromycin/administration & dosage , Clarithromycin/therapeutic use , Enzyme Inhibitors/administration & dosage , Enzyme Inhibitors/adverse effects , Enzyme Inhibitors/therapeutic use , Female , Helicobacter Infections/microbiology , Humans , Male , Metronidazole/administration & dosage , Metronidazole/therapeutic use , Omeprazole/administration & dosage , Omeprazole/therapeutic useABSTRACT
Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhosis and the role of portal hypertension in the development of SBP has been suggested. This study assessed the portal vein (PV) haemodynamic changes in patients with SBP. The study was conducted on 20 ascitic patients with SBP (GI), 20 ascitic patients without SBP (GII), 20 cirrhotic patients without ascites (GIII) and 20 healthy cross-matched controls (GIV). All groups were subjected to complete clinical assessment and routine laboratory investigations. Portal vein diameter, velocity and congestion index (CI) were assessed by Doppler ultrasound. The results showed no significant difference between SBP patients and ascitic patients without SBP as regard PV diameter, velocity or CI. Portal vein diameter was significantly wider in patients with SBP (14.9 +/- 2.08 mm) and cirrhotic ascites (14.15 +/- 2.3) than normal persons (10.55 +/- 2.24 mm) or cirrhotic compensated patients (13.15 +/- 1.6 mm). The mean velocity of PV was significantly lower in patients with SBP (10.4 +/- 2.11) and ascites (10.7 +/- 2.22) than normal persons (15.35 +/- 2.08) or cirrhotic compensated patients (14 +/- 2.6), with no significant difference between controls and cirrhotic compensated patients. The CI of PV was significantly higher in patients with SBP (0.1825 +/- 0.036) and ascites (0.1743 +/- 0.051) than controls (0.05 +/- 0.050) or cirrhotic compensated patients (0.0955 +/- 0.091). Cirrhotic compensated patients showed significantly wider PV (13.15 +/- 1.6) and higher congestion index (0.0955 +/- 0.091) than normal persons (10.55 +/- 2.24 and 0.05 +/- 0.050 respectively).
