Subject(s)
Cystitis/therapy , Fibroblast Growth Factor 7/therapeutic use , Hematopoietic Stem Cell Transplantation/adverse effects , Hemorrhage/therapy , Leukemia, Myeloid, Acute/therapy , Recombinant Proteins/therapeutic use , Antineoplastic Agents/therapeutic use , Child , Cystitis/etiology , Erythrocyte Transfusion , Female , Hemorrhage/etiology , Humans , Oxygen/therapeutic use , Recurrence , Transplantation, Homologous/adverse effects , Treatment OutcomeABSTRACT
We describe the first case, to our knowledge, of disseminated Mycobacterium bovis Bacillus Calmette-Guérin infection in a child with Bare Lymphocyte Syndrome type II after undergoing hematopoietic stem cell transplantation (HSCT). The patient presented 30 days post HSCT with fever and lymphadenitis. Lymph node, blood, and gastric aspirates were positive for M. bovis. The patient received a prolonged treatment course with a combination of isoniazid, levofloxacin, and ethambutol. Her course was further complicated by granulomatous lymphadenitis and otitis media associated with M. bovis that developed during immune suppression taper and immune reconstitution. Ultimately, the patient recovered fully, in association with restoration of immune function, and has completed 12 months of therapy.
