ABSTRACT
PURPOSE OF INVESTIGATION: A retrospective study to evaluate six cycles of cisplatin 40 mg/m2 on day 1 and ifosfamide 1,200 mg/m2 daily on days 1 to 4 with Mesna every four weeks as first line treatment for 29 patients with a diagnosis of uterine carcinosarcoma. MATERIALS AND METHODS: A total of 23 of 29 patients received high dose rate intracavitary vaginal cuff brachytherapy (VCBT) with two fractions of seven Gy each. Median age was 65 years (range 40-82); 13 (44.8%) had Stage I disease, three (10.3%) had Stage II, eight (27.6%) had Stage III, and five (17.2%) patients had Stage IV disease. RESULTS: Most common toxicities were anemia grade 1 (35%)/grade 2 (45%), and neutropenia grade 3 (17%)/grade 4 (6.9%). Eleven dose modifications, four treatment discontinuations, and one patient withdrawal occurred. At a median follow up of 45 months (range 9 to 144), Progression free survival (PFS) was 20% and overall survival (OS) was 40% for Stage IV, PFS 75% and OS 62.5% for Stage III, compared to a PFS 75% and OS 72.2% for Stages I-II. Median OS for the entire group was 12.43 years (95% CI 3.69 to inf); for Stage I-III 12.4 years (6.1 to inf), and for Stage IV 15.6 months (95% CI 9.4 to inf). CONCLUSIONS: Cisplatin and ifosfamide chemotherapy with VCBT was well tolerated and has promising activity in uterine carcinosarcoma.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Brachytherapy/methods , Carcinosarcoma/therapy , Uterine Neoplasms/therapy , Adult , Aged , Aged, 80 and over , Anemia/chemically induced , Carcinosarcoma/pathology , Chemoradiotherapy , Cisplatin/administration & dosage , Disease-Free Survival , Female , Humans , Ifosfamide/administration & dosage , Mesna/therapeutic use , Middle Aged , Neoplasm Staging , Neutropenia/chemically induced , Protective Agents/therapeutic use , Retrospective Studies , Treatment Outcome , Uterine Neoplasms/pathologyABSTRACT
This report discusses 27 patients with sigmoid volvulus treated at Jordan University Hospital (JUH) during a 15-year period. These patients represented 4.7 percent of adult patients treated for intestinal obstruction in the same period. The average age was 54.5 years, and none of the patients was institutionalized. Twenty-five patients presented with acute symptoms, and two had chronic symptoms. Sigmoidoscopic detorsion was achieved in 15 patients. Emergency resection was required in two of these patients: for the development of gangrene a few hours after detorsion in one patient and for recurrence within 24 hours in the other despite the presence of a rectal tube. Early recurrence occurred in two other patients and was managed endoscopically. Emergency surgery was performed in 10 other patients: for a failed endoscopic detorsion in three patients, for ulcerated and bleeding mucosa forecasting gangrene in another, and as a primary treatment in six patients who were either misdiagnosed or suspected to have gangrenous bowel. Elective resection was performed in 13 patients. The mortality rate was 15 percent (4/27) for the whole series and 33.3 percent (1/3) for those with gangrenous bowel.
Subject(s)
Intestinal Obstruction , Sigmoid Diseases , Adult , Aged , Aged, 80 and over , Colectomy , Colon, Sigmoid/pathology , Female , Gangrene , Humans , Intestinal Obstruction/complications , Intestinal Obstruction/diagnostic imaging , Intestinal Obstruction/pathology , Intestinal Obstruction/therapy , Male , Middle Aged , Radiography , Recurrence , Sigmoid Diseases/complications , Sigmoid Diseases/diagnostic imaging , Sigmoid Diseases/pathology , Sigmoid Diseases/therapy , SigmoidoscopyABSTRACT
We present 7 patients (5 adult females and 2 neonate males) with adrenal cysts. The cysts included 1 hydatid, 1 lymphatic and 5 pseudocysts. Three cysts were diagnosed preoperatively and all were resected surgically. The existence of true epithelial cysts of the adrenal gland is doubted by many authors; the present series includes most types of adrenal cyst.
