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J Mech Behav Biomed Mater ; 17: 333-6, 2013 Jan.
Article in English | MEDLINE | ID: mdl-23127640

ABSTRACT

Biocompatible polymers are commonly used to fabricate microfluidic channels for the study of biological flows such as blood microflows. The most common of these materials is polydimethylsiloxane (PDMS) which is very hydrophobic. Oxygenated plasma is advocated to treat the PDMS with reported decreases in contact angle i.e. increase the hydrophilicity of the material in order to make the liquid flow easily. All contact angle studies have been reported with water. Here the contact angles of blood suspensions, in saline and native plasma, are compared to each other and water on common microfluidic chip materials. The hydrophilic effect of plasma-treatment on PDMS is not found to be as significant with blood suspensions as it is with water. Red blood cells suspended in native plasma are found to have a greater contact angle than those suspended in saline.


Subject(s)
Blood/drug effects , Hydrodynamics , Microfluidic Analytical Techniques/methods , Animals , Biocompatible Materials/chemistry , Biocompatible Materials/pharmacology , Hematocrit , Hydrophobic and Hydrophilic Interactions , Suspensions , Swine
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