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J Pharm Sci ; 66(11): 1623-5, 1977 Nov.
Article in English | MEDLINE | ID: mdl-915742

ABSTRACT

8-Monosubstituted and 5,8-disubstituted psoralen derivatives were prepared, and their skin-photosensitizing activity was evaluated. The results were correlated in terms of molecular configuration, and 8-allyloxypsoralen can be considered was a new agent of potent photodynamic activity.


Subject(s)
Coumarins/chemical synthesis , Ficusin/chemical synthesis , Light , Skin/radiation effects , Adjuvants, Pharmaceutic/chemical synthesis , Animals , Ficusin/pharmacology , Furocoumarins , Guinea Pigs , Skin/drug effects , Structure-Activity Relationship
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