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Antimicrob Agents Chemother ; 42(1): 37-9, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9449257

ABSTRACT

The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds.


Subject(s)
Peptides, Cyclic/therapeutic use , Pneumocystis/drug effects , Pneumonia, Pneumocystis/drug therapy , Animals , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Mice , Mice, Inbred BALB C , Mice, Nude , Microbial Sensitivity Tests , Peptides, Cyclic/chemistry , Pneumocystis/isolation & purification , Rats
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