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Nanoscale ; 12(8): 4839-4845, 2020 Feb 27.
Article in English | MEDLINE | ID: mdl-32065596

ABSTRACT

Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.


Subject(s)
Drug Carriers , Gene Transfer Techniques , Iron , Metal-Organic Frameworks , RNA , Cell Line, Tumor , Drug Carriers/chemistry , Drug Carriers/pharmacokinetics , Drug Carriers/pharmacology , Humans , Iron/chemistry , Iron/pharmacokinetics , Iron/pharmacology , Metal-Organic Frameworks/chemistry , Metal-Organic Frameworks/pharmacokinetics , Metal-Organic Frameworks/pharmacology , RNA/chemistry , RNA/pharmacokinetics , RNA/pharmacology
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