Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism.

The regulatory and adaptive status was determined in 202 healthy subjects by the parameters of the cardiorespiratory synchronism probe. We performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase TPH1 (A218C polymorphism) and TPH2 (G703T polymorphism), and serotonin receptors (HTR2C and HTR2A genes). The association of the regulatory and adaptive status of a subject with the polymorphism of serotonergic mediator system genes was revealed.

Detection of flashing areas attributed to the frog cardiac function in the vagosympathetic trunk placed into a high frequency electric field.

In a high frequency electric field, two flashing areas were observed during each contraction of the heart in the vagosympathetic trunk of a paralyzed frog with an intact brain. One area with a higher diameter was moving along the nerve from the heart at a speed of 16.6 ± 0.2 m/s. It was identified as afferent. Another area with a smaller diameter was spreading along the nerve towards the venous sinus of the frog heart at a speed of 5.6 ± 0.3 m/s, and it was efferent.

[Cardiorespiratory synchronism: revealing in human, dependence on properties of nervous system and functional states of an organism]. / Serdechno-dykhatel'nyi sinkhronizm: vyiavlenie u cheloveka, zavisimost' ot svoistv nervnoi systemy i funktsional'nykh sostoianii organizma.

Cardiorespiratory synchronism (CRS) shows that at the breathing frequency, which as usual exceeds the baseline heart rhythm, the heart makes one contraction per each breathing. It is shown that CRS arises as a result of reproduction by the heart the rhythm of signals, coming to the heart via vagus nerves. CRS characterized by the synchronization range, duration of its development after the beginning of the rapid respiration, difference between the baseline heartbeat frequency and lower limit of synchronization range. The CRS parameters were determined in humans at the age of 5-65. The CRS parameters depends on nervous system type, vegetative tonus of the nervous system and functional states of an organism.

[Effect of regulatory peptides on the effect of cardiorespiratory synchronization in patients with heart diseases]. / Deistvie reguliatornykh peptidov na éffekt kardiorespiratornyi sinkhronizatsii u bol'nykh s patologiei serdtsa.

A long-acting somatostatin analogue (sandostatin) and synthetic opioid dalargin were examined for the effect on the heart rhythm under the cardiorespiratory synchronization test in patients with heart disease. In high-frequency respiration synchronized with photostimulator flashes the patients exhibited cardiorespiratory synchronism when heart rate corresponds exactly to respiration rate. A spontaneous change of the respiration rate entailed corresponding changes in the heart rate. This allowed regulation of the heart rhythm. Intravenous injection of sandostatin or dalargin extended the range of the cardiorespiratory synchronization. The latter points to involvement of peptides in mechanisms of heart taking of the control signals coming from the central nervous system.

[Control of the cardiac rhythm in the cat by stimulation of the carotid sinus nerve with pulse bursts]. / Upravlenie ritmom serdtsa koshki pri razdrazhenii sinokarotidnogo nerva zalpami impul'sov.

The cat heart rate responded with a systole to a burst stimulation of the sinocarotid nerve. A change of the stimulation frequency entailed a respective change in the systole frequency within the range 179.2 +/- 1.3-173.2 +/- 1.5 systoles per minute.

[Use of cardiorespiratory synchronization in the differential diagnosis of arrhythmia]. / Primenenie kardiorespiratornoi sinkhronizatsii dlia differentsial'noi diagnostiki aritmii.

A method was proposed for differential diagnosis of functional and organic cardiac arrhythmias. It is based on the concept that the nervous system produces a trigger impact on the heart. Cardiorespiratory synchronization is one of the manifestations of the impact. The advantage of the method is that it takes only several minutes and requires no expensive equipment. In fact it may be used at any medical institution. It is particularly effective in mass surveys of persons with cardiac rhythm disturbances of unknown etiology, which are identified for the first time.

[Effects of high-frequency artificial respiration on the rhythm of heart contraction in cats]. / Vliianie vysokochastotnogo iskusstvennogo dykhaniia na ritm sokrashchenii serdtsa koshki.

High-frequency artificial hyperventilation of cat lung with a rate above the initial rhythm of the heart reconstructs the rhythm so that each breathing cycle coincides with one systole of the heart. Synchronization of breathing movements and heart systoles is easily removed by atropine, and cold blockade of vagus nerves by open artificial pneumothorax.

[Analysis of the effect of volley stimulation of the vago-sympathetic trunk on establishment of the heart rate]. / Analiz vliianiia zalpovogo razdrazheniia vago-simpaticheskogo stvola na formirovanie ritma serdtsa.

In electrical stimulation of the frog vago-sympathetic nerve, oscillations of the cardiac rhythm depended upon changes of the pacemaker MPs.