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Biofizika ; 59(4): 785-9, 2014.
Article in Russian | MEDLINE | ID: mdl-25707247

ABSTRACT

The antitumor activity of polyacrylates of the noble metals containing argentum (argacryl), aurum (auracryl) and platinum (platacryl) has been studied using experimental murine solid tumor models (Lewis lung carcinoma and Acatol adenocarcinoma). It has been found that polyacrylates of the noble metals are capable of inhibiting tumor development by 50-90% compared to control. Auracryl that inhibites the growth of Lewis lung carcinoma and Acatol adenocarcinoma by 80 and 90%, respectively, compared to control is the most efficient among the tested compounds and can be recommended for the further profound preclinical studies.


Subject(s)
Acrylic Resins/pharmacology , Adenocarcinoma/drug therapy , Antineoplastic Agents/pharmacology , Carcinoma, Lewis Lung/drug therapy , Gold/pharmacology , Platinum/pharmacology , Silver/pharmacology , Acrylic Resins/chemistry , Adenocarcinoma/metabolism , Adenocarcinoma/pathology , Animals , Antineoplastic Agents/chemistry , Carcinoma, Lewis Lung/metabolism , Carcinoma, Lewis Lung/pathology , Drug Screening Assays, Antitumor , Gold/chemistry , Mice , Mice, Inbred BALB C , Platinum/chemistry , Silver/chemistry
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