ABSTRACT
The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol SOD, activity increased. GSH-Px activity and MDA levels in animals of all groups were similar. In ethanol treated rats NO levels significantly decreased as compared to the animals of the control group (6.45±0.24 nmol/g vs 11.05±0.53 nmol/g, p.
Subject(s)
Cerebral Cortex , Ethanol , Fatty Acids, Omega-3 , Nitric Oxide , Rats, Wistar , Superoxide Dismutase , Animals , Male , Rats , Fatty Acids, Omega-3/pharmacology , Cerebral Cortex/metabolism , Cerebral Cortex/drug effects , Nitric Oxide/metabolism , Superoxide Dismutase/metabolism , Glutathione Peroxidase/metabolism , Antioxidants/pharmacology , Malondialdehyde/metabolismABSTRACT
OBJECTIVE: Study aimed to determine the effects of zinc supplementation/deficiency on the histological structure and elements levels in bone tissue in ovariectomized rats. METHODS: The study included 40 Sprague-Dawley type adult female rats, divided as follows: Control, ovariectomized, ovariectomized + zinc supplemented, ovariectomized + zinc deficient groups. At the end of the study bone tissues (femur) were collected to determine the levels of calcium, phosphorus, magnesium, zinc, iron, aluminium, chrome, lithium, lead, nickel, and manganese. The bone tissue was examined for histopathology. RESULTS: Ovariectomy leaded to significant decrease in magnesium. Zinc supplementation to ovariectomized rats restored the reduced calcium, phosphorus, zinc. However, zinc deficiency in ovariectomized rats further reduced calcium, phosphorus, zinc, and manganese levels. Zinc deficiency in ovariectomized significantly increased Al, Cr, Li, Pb, and Ni levels. Tissue integrity was impaired due to ovariectomy and zinc deficiency. CONCLUSION: Ovariectomy and zinc deficiency leads significant decreases elements of the bone.
Subject(s)
Bone and Bones/drug effects , Bone and Bones/pathology , Dietary Supplements , Ovariectomy , Zinc/deficiency , Zinc/pharmacology , Animals , Bone and Bones/metabolism , Female , Rats , Rats, Sprague-DawleyABSTRACT
The external carotid artery (ECA) is the main artery of the head and the neck region. Carotid bifurcation (CB), which is one of the place where the atherosclerotic plaques are most commonly seen. The surgical procedure of these plaques which causes cerebral vascular accident (CVA) is carotid endarterectomy. In this surgical procedure, the knowledge of the anatomical courses and variations of the carotid artery increased the surgery performance. In our study, we aimed to introduce the course, the location and the variation of the ECA's and their branches. This study is carried out on multidetector computerized tomography angiography of the ECA's of 50 men and 50 women, totally 200 ECA's (100 right, 100 left). The measurement of the inner diameter of the common carotid artery (CCA) and the ECA was evaluated. The location of the CB was determined and its vertical distance to the gonion measured. We found that the superior thyroid artery (STA) originated from the CCA, the CB and the ECA. The vertical distances between the CB and the STA, lingual (LA), facial (FA) occipital (OA) were measured. The ECA and its branches were recorded. We believe that the assessment of the ECA morphometrically may comprise control groups of diseases related to the vessel diameter and this data may be used as reference in clinic and surgery. Knowing the anatomical details and variations is vital to prevent unpredictable complications in surgery.
La arteria carótida externa (ACE) es la principal arteria de la cabeza y de la región del cuello. La bifurcación carotídea (BC) es uno de los lugares donde las placas ateroscleróticas son más frecuentes. El procedimiento quirúrgico para tratar estas placas que causan el accidente vascular cerebral (AVC) es la endarterectomía carotídea. En este procedimiento quirúrgico, el conocimiento de los cursos anatómicos y variaciones de la arteria carótida aumenta el rendimiento de la cirugía. El objetivo de nuestro estudio fue presentar el trayecto, localización y variación de la ACE y sus ramas. El estudio se realizó mediante angiografía multidetector por tomografía computarizada de la ACE de 50 hombres y 50 mujeres, totalizando 200 ACE (100 derechas y 100 izquierdas). Se evaluaron el diámetro interior de la arteria carótida común (ACC) y la ACE. Se determinó la ubicación de la BC y se midió la distancia vertical hasta el gonion. Se observó que la arteria tiroidea superior (ATS) se originó desde la ACC, la BC y la ACA. Las distancias verticales entre la BC, y las arterias tiroídea superior, lingual (AL), facial (AF) y occipital (AO) fueron medidas. La ACE y sus ramas se registraron. Creemos que la evaluación morfométrica de la ACE puede comprender grupos de control de las enfermedades relacionadas con el diámetro de los vasos, y estos datos pueden ser utilizados como referencia clínica y quirúrgica. El conocimiento de los detalles anatómicos y variaciones es de vital importancia para evitar complicaciones imprevisibles en la cirugía.
