ABSTRACT
We reviewed the pathologic slides and clinical data of 44 patients with mucoepidermoid carcinomas of major and minor salivary glands. There were 14 well-differentiated, 20 intermediate, and ten poorly differentiated tumors. Two tumors appeared to have only expansive growth. All of the others were invasive, and we identified two patterns of invasion: broad pushing borders and infiltrative permeation. Infiltrative permeation was seen in 13 of 34 well-differentiated and intermediate tumors of which four (31%) metastasized, and in eight of ten poorly differentiated tumors of which five (63%) metastasized. Six of the nine patients with metastases died of carcinoma. Three patients who died with well-differentiated or intermediate tumors survived 10.5 years after diagnosis. Three patients died of poorly differentiated carcinoma less than one year after diagnosis. No patient died of local disease only, and no tumor with a broad pushing border metastasized. Size of tumor, site of origin, tumor cell mitotic rate, and age and sex of the patient had little, if any, effect on prognosis. A combination of tumor differentiation and pattern of invasion were the most useful factors in predicting carcinoma behavior.
Subject(s)
Carcinoma/pathology , Salivary Gland Neoplasms/pathology , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplasm Recurrence, Local/pathology , PrognosisABSTRACT
A case is reported of metastatic adenosquamous carcinoma that developed in a patient one year after diagnosis of adenocarcinoma of the prostate by transurethral resection of the prostate (TURP). Prostatic origin of the neoplasm was proved by immunoperoxidase staining for prostatic acid phosphatase in the metastases as well as demonstration of both glandular and squamous differentiation in tumor within the prostate on repeat TURP. This change in tumor differentiation occurred despite the fact that the patient had received no estrogen or radiation. The metastases showed remarkable response when the patient later began diethylstilbestrol (DES) therapy.
Subject(s)
Adenocarcinoma/pathology , Carcinoma, Squamous Cell/pathology , Prostatic Neoplasms/pathology , Acid Phosphatase/analysis , Adenocarcinoma/secondary , Adenocarcinoma/therapy , Aged , Carcinoma, Squamous Cell/secondary , Carcinoma, Squamous Cell/therapy , Diethylstilbestrol/therapeutic use , Humans , Immunoenzyme Techniques , Male , Thoracic Neoplasms/secondary , Thoracic Neoplasms/therapyABSTRACT
We report a case of 2 concurrent serious renal problems in opposite kidneys. The patient presented with gross hematuria, which resulted in a diagnosis of transitional cell carcinoma of the renal pelvis and tuberculosis of the contralateral kidney. Intraoperative nephroscopy allowed for appropriate diagnosis and surgical therapy.
