ABSTRACT
El virus de la hepatitis E (VHE) es un virus de la familia Hepeviridae, del que hay descritos 4 genotipos diferentes. Los genotipos 1 y 2 suelen causar hepatitis agudas que cursan como brotes epidémicos en las regiones endémicas de Asia y África. Los genotipos 3 y 4 causan casos de hepatitis aguda esporádicos en Europa y Norteamérica, donde se empieza a considerar una zoonosis. Habitualmente, el cuadro clínico se resuelve de manera espontánea, pero en los últimos años se están detectando casos que evolucionan a hepatopatía crónica principalmente en pacientes inmunodeprimidos (trasplante de órgano sólido, linfomas, virus de la inmunodeficiencia humana [VIH], inmunodeficiencias primarias, pacientes en tratamiento con corticoides e inmunosupresores, etc.). Presentamos a continuación el caso de un varón sano inmunocompetente que presentó un cuadro de hepatitis aguda por VHE, que en el plazo de año y medio evolucionó a hepatopatía crónica, con fibrosis grado III/IV en la biopsia hepática (AU)
Hepatitis E virus (HEV) is a Herpesvirus, with four different genotypes. Genotypes 1 and 2 often cause acute hepatitis, which presents as outbreaks in endemic regions of Asia and Africa. Genotypes 3 and 4 cause sporadic cases of acute hepatitis in Europe and North America, where it is considered a zoonosis. Symptoms usually resolve spontaneously, but in recent years cases have been detected that progress to chronic liver disease mainly in immunocompromised patients (patients with solid organ transplants, lymphoma, human immunodeficiency virus, primary immunodeficiencies, and those under treatment with corticosteroids and immunosuppressive agents..). We report the case of a healthy, immunocompetent man who developed an episode of acute HEV hepatitis, which progressed to chronic liver disease with fibrosis grade III/IV in the liver biopsy within a year and half (AU)
Subject(s)
Humans , Male , Aged , Hepatitis E/complications , Hepatitis, Chronic/complications , Liver Cirrhosis/etiology , Hepatitis E virus/pathogenicityABSTRACT
Hepatitis E virus (HEV) is a Herpesvirus, with four different genotypes. Genotypes 1 and 2 often cause acute hepatitis, which presents as outbreaks in endemic regions of Asia and Africa. Genotypes 3 and 4 cause sporadic cases of acute hepatitis in Europe and North America, where it is considered a zoonosis. Symptoms usually resolve spontaneously, but in recent years cases have been detected that progress to chronic liver disease mainly in immunocompromised patients (patients with solid organ transplants, lymphoma, human immunodeficiency virus, primary immunodeficiencies, and those under treatment with corticosteroids and immunosuppressive agents..). We report the case of a healthy, immunocompetent man who developed an episode of acute HEV hepatitis, which progressed to chronic liver disease with fibrosis grade III/IV in the liver biopsy within a year and half.
