ABSTRACT
Mucinous carcinoma of the breast is a type of well-differentiated adenocarcinoma, a rare subtype of infiltrating ductal carcinoma. It represents approximately 2% of all invasive breast carcinomas. The mean age of presentation is 65 years, with an incidence of 1% in women younger than 35 years. Depending on the mucin content of the carcinoma, they are described as pure or mixed; the distinction between the 2 is important for prognosis and treatment. The treatment of special types of breast cancer is still controversial due to the limited amount of evidence, however, the main treatment for breast cancer is still surgery. We present a case of a 29-year-old patient with mucinous carcinoma of the breast with a delay in its management, but with a favorable postoperative result.
ABSTRACT
Mucopolysaccharidosis type IV or Morquio Syndrome, is a lysosomal deposit disease, of autosomal recessive inheritance with a similar incidence in men and women. The clinical picture is of variable expressiveness, its phenotype is characterized by skeletal dysplasia that includes neck and short trunk, short stature, keel thorax, kyphosis, scoliosis, genus valgus, flat foot, coxa valga, gait disorders, instability of the cervical spine and wedge or ovoid vertebrae. The treatment is symptomatic, with enzyme replacement. We present a series of 5 cases, the product of 2 couples, with a confirmed diagnosis of Mucopolysaccharidosis type IV, and different clinical presentation.
ABSTRACT
Resumen Introducción: La mortalidad fetal intrauterina (MFIU) es un problema de salud pública por sus elevadas tasas a nivel mundial y en poblaciones de ingresos medios y bajos. Sin embargo, es un evento poco estudiado y carece de visibilidad en las políticas, planes y programas de salud pública. Objetivo: Analizar los determinantes sociodemográficos y clínicos asociados a la MFIU en Pasto-Colombia. Materiales y métodos: Estudio analítico observacional con 88 muertes fetales como casos y 88 nacidos vivos como controles, ocurridas en hospitales de tercer nivel en el municipio de Pasto-Colombia durante 2010-2012, para determinar la relación entre mortalidad fetal, condiciones clínicas (complicaciones del embarazo, edad gestacional, peso al nacer, controles prenatales, antecedentes obstétricos, tóxicos o aborto) y sociodemográficas (edad, etnia, ocupación, estado civil, estrato, zona de residencia, escolaridad, paridad, condición de desplazamiento, embarazo planeado). Resultados: Se identificó que el riesgo de mortalidad fetal es significativamente menor con el incremento de la edad gestacional (OR ajustado=0,76 IC95% 0,62; 0,93) y el peso al nacer (OR ajustado=0,99 IC95% 0,98; 0,99). Otras variables clínicas y sociodemográficas no se asociaron. Conclusión: Los resultados proveen evidencia para la planificación de planes de intervención que prioricen a mujeres cuyo feto tenga un peso inferior al normal y un riesgo de nacimiento prematuro.
Abstract Introduction: Intrauterine fetal mortality (IUFM) is a public health problem because of its high rates worldwide and in low-and middle-income populations. However, it is a little-studied event and lacks visibility in public health policies, plans and programs. Objective: To analyze the sociodemographic and clinical determinants associated with IUFM in Pasto-Colombia. Materials and methods: A study, that includes 88 fetal deaths as cases and 88 live births as controls occurred in third level hospitals in Pasto-Colombia during 2010 and 2012, was carried out to determine the relationship between fetal mortality, clinical conditions (complications of pregnancy, gestational age, birth weight, prenatal controls, pathological and toxic medical history, or abortion) and sociodemographic conditions (age, ethnicity, occupation, marital status, stratum, area of residence , schooling, parity, displacement condition, planned pregnancy). Results: It was identified that the risk of fetal mortality is significantly lower with the increase in gestational age (OR ajustado = 0.76 IC95% 0.62; 0.93) and birth weight (OR ajustado = 0.99 IC95% 0.98; 0.99). Other clinical and sociodemographic variables were not associated. Conclusion: The results provide evidence for planning intervention plans that prioritize women whose fetus has a lower-than-normal weight and a risk of premature birth.
