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1.
Bull Soc Pathol Exot ; 108(4): 255-61, 2015 Oct.
Article in French | MEDLINE | ID: mdl-26296430

ABSTRACT

The aim of this study was to describe the clinical and immunological profile of patients infected with HIV after initiation of antiretroviral therapy. Sociodemographic characteristics, clinical and immunological patients were recorded. Chi square test and Mann-Whitney were used to compare variables. The multivariate regression model identified risk factors. So that, 936 (56.2%) patients were in stages III and IV of the WHO and 65.2% at an advanced stage of the disease. Factors associated with initiation at an advanced stage, were male sex (p = 0.007) and time to diagnosis (p = 0.005). In 2/3 cases, treatment is started at an advanced stage of disease. It is therefore important to intensify awareness campaigns for early detection and encourage patients to ensure regular medical follow-up screening.


Subject(s)
Anti-Retroviral Agents/therapeutic use , HIV Infections/drug therapy , HIV Infections/epidemiology , HIV Infections/immunology , Adult , Anti-HIV Agents/therapeutic use , CD4 Lymphocyte Count , Cameroon/epidemiology , Cross-Sectional Studies , Female , HIV-1 , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors
2.
Bull Soc Belge Ophtalmol ; (305): 7-12, 2007.
Article in French | MEDLINE | ID: mdl-18018421

ABSTRACT

PURPOSE: This study aimed to identify the ocular complications of HIV/AIDS in Cameroon and to determine if there is any correlation between their occurrence and the level of CD4 lymphocytes count. MATERIAL AND METHODS: This prospective study was carried out at the General Hospital, Douala, from October 2004 to September 2005. All HIV positive patients with known CD4 count were retained for the study. Each patient had an exhaustive ocular examination. RESULTS: A total of 57 patients including 30 females (52.9%) and 27 males (47.4%) were examined. The mean age was 38.9 years +/- 10.3. The eye examination was pathological in 36 patients (63.2%) and normal in 21 patients (36.8%). An ocular complaint was the inaugural manifestation of the disease in 31.6% of patients. The principal lesions of the anterior segment were herpetic keratitis (10.5%) and herpes zoster ophthalmicus (12.3%). The most common posterior segment lesions were cytomegalovirus retinitis (14%) and uveitis (15.8%). The mean CD4 count in our series was 118.3/mm3 +/- 106.7. 91.7% of patients with ocular complications have a CD4 count of less than 200/mm3. A non linear correlation was found between the CD4 level and the occurrence of ocular complications. CONCLUSION: With the improvement of access to antiretroviral treatment, the ocular complications of HIV/AIDS are more common. The role of the ophthalmologist is therefore essential in the diagnosis and management of these patients.


Subject(s)
Acquired Immunodeficiency Syndrome/complications , CD4 Lymphocyte Count , Eye Diseases/immunology , Adult , Cameroon , Eye Diseases/diagnosis , Female , Humans , Male , Prospective Studies
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