ABSTRACT
A 44-year-old woman, victim of a road accident in Mali was diagnosed with left knee arthritis. Joint effusion aspiration and subcutaneous surgical biopsies were positive for a melanized asexual ascomycete. Using microscopy and molecular biology, the fungus was identified as Curvularia sp. In vitro antifungal susceptibility was determined by the EUCAST broth microdilution reference technique and by E-test. The patient was treated with liposomal amphotericin B before posaconazole relay. Mycological samples obtained 10 days after starting the antifungal therapy by liposomal amphotericin B were negative in culture. Curvularia spp. are environmental fungi which can under certain conditions be pathogenic for humans.
Subject(s)
Accidents, Traffic , Arthritis, Infectious/microbiology , Ascomycota , Knee Injuries/complications , Knee Injuries/microbiology , Adult , Antifungal Agents/therapeutic use , Arthritis, Infectious/diagnosis , Arthritis, Infectious/drug therapy , Arthritis, Infectious/immunology , Ascomycota/isolation & purification , Ascomycota/physiology , Fatal Outcome , Female , France , Humans , Immunocompetence , Knee Injuries/drug therapy , Knee Injuries/immunology , Knee Joint/microbiology , Mali , Mycoses/complications , Mycoses/diagnosis , Mycoses/drug therapy , Mycoses/microbiology , Quadriplegia/etiology , Quadriplegia/microbiology , Spinal Cord Injuries/complications , Spinal Cord Injuries/microbiology , Travel-Related IllnessABSTRACT
In this study we have investigated the preservation of craniotomy bone flaps within the abdominal wall and the use of such bone flaps for cranioplasty in the early postoperative period. The craniotomy flaps were implanted into a "pocket" between abdominal fat and muscle of adult rabbits, and were later used as autologous grafts in cranioplasty. The flaps were analyzed by histopathologic and microdensitometric methods. In 36 of the flaps, new bone formation near the periosteum was observed. The bone flap-cranium relationship was supplied by a bony tissue. Microdensitometric analysis showed increased optic densities in the experimental group.
