[Beta blocker induced depression. A case report]. / Depresión inducida por betabloqueantes. A prospósito de un caso.

INTRODUCTION: Although association between beta blockers and depression has been reported since decades ago, the subject is still controversial. Most evidence supporting an association has been based on case reports or case series. Epidemiologic studies and randomized clinical trials have not generally supported this association. If this association exists, possible causes of disparity of findings may include methodological difficulties, and/or weak association. CASE SUMMARY: We present a case of a 67 year old woman, without personal history of psychiatric illness or stress factors, who develops a depressive episode after initiating treatment with atenolol. The symptoms remitted rapidly when atenolol was discontinued, and an antidepressant was prescribed during a short period. CONCLUSIONS: This case report suggests the existence of an association between a beta blocker, atenolol, and depression.

Depresión inducida por betabloqueantes. A propósito de un caso / Beta blocker induced depression. A case report

Introducción. Aunque desde hace décadas se ha señalado la asociación entre betabloqueantes y depresión, este tema permanece en controversia. La asociación ha sido señalada fundamentalmente en estudios de casos únicos o series de casos, mientras que los estudios epidemiológicos y ensayos clínicos aleatorizados han ofrecido escaso sustento a esta hipótesis. De existir tal asociación, las posibles causas de la disparidad de hallazgos serían las dificultades metodológicas, y/o que se trate de una asociación débil.Caso clínico. Se presenta un caso clínico de una paciente de 67 años, sin antecedentes psiquiátricos ni factores estresantes, que desarrolla un episodio depresivo tras iniciar tratamiento con atenolol, el cual remite rápidamente tras la supresión del mismo y de iniciar tratamiento antidepresivo durante un corto período de tiempo.Conclusiones. Este caso sugiere la existencia de asociación entre un betabloqueante, el atenolol, y la depresión

Introduction. Although association between beta blockers and depression has been reported since decades ago, the subject is still controversial. Most evidence supporting an association has been based on case reports or case series. Epidemiologic studies and randomized clinical trials have not generally supported this association. If this association exists, possible causes of disparity of findings may include methodological difficulties, and/or weak association.Clinical case. We present a case of a 67 year old woman, without personal history of psychiatric illness or stress factors, who develops a depressive episode after initiating treatment with atenolol. The symptoms remitted rapidly when atenolol was discontinued, and an antidepressant was prescribed during a short period.Conclusions. This case report suggests the existence of an association between a beta blocker, atenolol, and depression

Doble episodio de agranulocitosis probablemente causada por metamizol / Dual agranulocytosis episode likely resulting from metamizole use

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