ABSTRACT
OBJECTIVE: Determining antimicrobial indication and frequency of use in hospitalised patients. MATERIALS AND METHODS: Date and place of work: May 1st to June 30th 2006, Colima, Mexico. An analytical cross-sectional study was carried out; it involved 400 patients from both sexes hospitalised in different second level hospital departments. The variables analysed were: age, gender and the department from which each patient was referred. Antibiotics were evaluated according to type, frequency of use, whether use was prophylactic or therapeutic, whether treatment design was monotherapeutic or mixed, the amount of time taken from being admitted to hospital to beginning treatment, the number of days of treatment, the motive for changing or suspending therapeutic design, the number of patients receiving complete design and the number of patients for whom cultures were or were not done. RESULTS: 63% of the patients received antibiotic therapy, antibiotic use being prophylactic in 46 % of them. The General Surgery Department presented statistically significant antibiotic use association (3.9 OR; 1.7-8.9 CI; p<0.01) and the Internal Medicine Department presented a protector factor (0.5 OR, 0.3-0.8 CI, p<0.01). Betalactamic antibiotics were most frequently used (47%). Mean antibacterial treatment lasted 3.8+/-3.3 days and the amount of time taken from hospital admittance to beginning antibiotic treatment was 13.6+/-47.4 hours. Cultures were done for 2.8% of the patients. CONCLUSION: 63% of hospitalised patients received antibiotic therapy. The prophylactic impact of antibiotics on intrahospital infection frequency and characteristics should be evaluated and their cost-benefit calculated.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Hospitalization , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Cross-Sectional Studies , Drug Utilization/statistics & numerical data , Female , Humans , Infant , Male , Middle Aged , Risk Factors , Young AdultABSTRACT
Objetivo Determinar la frecuencia del uso e indicaciones de antimicrobianos en pacientes hospitalizados. Métodos Fecha y lugar de ejecución: Del 1º de mayo al 30 de junio de 2006. Colima, México. Se realizó un estudio transversal analítico. Se incluyeron 400 pacientes de ambos sexos hospitalizados en cualquier servicio de un hospital de segundo nivel. Las variables estudiadas fueron: edad, género, servicio de procedencia; de los antibióticos se evalúo su frecuencia, tipo de antibiótico, si se utilizó en forma profiláctica o terapéutica, como monoterapia o terapia mixta, tiempo de inicio posterior al ingreso, días de tratamiento, motivo de cambio o suspensión del esquema terapéutico, cuantos tuvieron esquema completo, si hubo o no cultivo. Resultados El 63 por ciento de los pacientes estudiados recibieron antibioticoterapia y en 46 por ciento su uso fue profiláctico. Cirugía general fue el servicio que presentó una asociación estadística significativa para uso de antibióticos (OR 3,9, IC 1,7-8,9; p < 0,01); mientras que el servicio de medicina interna presentó un factor protector (OR 0,5, IC 0,3-0,8, p < 0,01) Los betalactámicos fueron el grupo más frecuentemente utilizado (47 por ciento). El promedio de días de tratamiento antibacteriano fue 3,8 ± 3,3 días y el tiempo desde su ingreso a la aplicación de antibiótico fue de 13,6± 47,4 horas. El 2,8 por ciento de pacientes tenían cultivo. Conclusiones El 63 por ciento de los pacientes hospitalizados recibieron antibioticoterapia. Es necesario evaluar el impacto profiláctico de los antibióticos sobre la frecuencia y características de las infecciones intrahospitalarias y determinar su costo beneficio.
Objective Determining antimicrobial indication and frequency of use in hospitalised patients. Materials and methods Date and place of work: May 1st to June 30th 2006, Colima, Mexico. An analytical cross-sectional study was carried out; it involved 400 patients from both sexes hospitalised in different second level hospital departments. The variables analysed were: age, gender and the department from which each patient was referred. Antibiotics were evaluated according to type, frequency of use, whether use was prophylactic or therapeutic, whether treatment design was monotherapeutic or mixed, the amount of time taken from being admitted to hospital to beginning treatment, the number of days of treatment, the motive for changing or suspending therapeutic design, the number of patients receiving complete design and the number of patients for whom cultures were or were not done. Results 63 percent of the patients received antibiotic therapy, antibiotic use being prophylactic in 46 percent of them. The General Surgery Department presented statistically significant antibiotic use association (3.9 OR; 1.7-8.9 CI; p<0.01) and the Internal Medicine Department presented a protector factor (0.5 OR, 0.3-0.8 CI, p<0.01). Betalactamic antibiotics were most frequently used (47 percent). Mean antibacterial treatment lasted 3.8±3.3 days and the amount of time taken from hospital admittance to beginning antibiotic treatment was 13.6±47.4 hours. Cultures were done for 2.8 percent of the patients. Conclusion 63 percent of hospitalised patients received antibiotic therapy. The prophylactic impact of antibiotics on intrahospital infection frequency and characteristics should be evaluated and their cost-benefit calculated.