ABSTRACT
OBJECTIVE: Few studies have examined the association between ABO blood grouping and head and neck cancer. This retrospective review examined the association between blood group and laryngeal cancer incidence and patient mortality. METHODS: Of 271 patients treated for squamous cell laryngeal carcinoma (1997-2002), 143 patients with supraglottic, glottic and subglottic tumours were included; 128 patients were excluded. The blood group characteristics of patients and healthy blood donors were compared. RESULTS: There was no significant correlation between blood type and laryngeal carcinoma incidence or mortality. Type A blood was commoner in African Americans with laryngeal cancer than Caucasian patients, but not significantly so. As expected, five-year survival rates were lower in patients with more advanced stage cancer (p < 0.0001). CONCLUSION: Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.
Subject(s)
ABO Blood-Group System , Carcinoma, Squamous Cell/epidemiology , Glottis , Laryngeal Neoplasms/epidemiology , Adult , Black or African American/statistics & numerical data , Carcinoma, Squamous Cell/blood , Carcinoma, Squamous Cell/mortality , Epidemiologic Methods , Female , Humans , Laryngeal Neoplasms/blood , Laryngeal Neoplasms/mortality , Male , Smoking/epidemiology , Socioeconomic Factors , United States/epidemiology , White People/statistics & numerical dataABSTRACT
The aqueous extract of Balanites aegyptiaca bark, which is used in Sudanese folk medicine in the treatment of jaundice, was without effect when studied on rabbit intestine, rabbit aortic strip, rat stomach strip, rat uterus and rat phrenic nerve-diaphragm in a dose up to 10 mg/mL gut bath. In a larger dose (25 mg) the extract decreased significantly the contractility and the rate of the isolated perfused rabbit heart. Administration of the aqueous extract to biliary duct-ligated rats, showed a dose-dependent significant decrease in serum bilirubin level. The chronic and subchronic toxicity investigations indicate the safety of the aqueous extract at a dose level which showed a significant decrease in serum bilirubin level in experimental obstructive jaundice in rats.
