ABSTRACT
Orthopaedic materials may improve its capacity to resist bacterial adherence, and subsequent infection. Our aim was to test the bacterial adherence to alpha-tocopherol (frequently named vitamin E, VE) doped or blended UHMWPE with S. aureus and S. epidermidis, compared to virgin material. Collection strains and clinical strains isolated from patients with orthopaedic infections were used, with the biofilm-developing ability as a covariable. While collection strains showed significantly less adherence to VE-UHMWPE, some clinical strains failed to confirm this effect, leading to the conclusion that VE doped or blended UHMWPE affects the adherence of some S. epidermidis and S. aureus strains, independently of the concentration in use, but the results showed important intraspecies differences and cannot be generalized.
Subject(s)
Bacterial Adhesion/drug effects , Polyethylenes/chemistry , Staphylococcus aureus/drug effects , Staphylococcus epidermidis/drug effects , Vitamin E/chemistry , Vitamin E/pharmacology , Biocompatible Materials/chemistry , Hydrophobic and Hydrophilic Interactions , Photoelectron Spectroscopy , Staphylococcus aureus/physiology , Staphylococcus epidermidis/physiology , Surface PropertiesSubject(s)
Actinomycetales Infections/diagnosis , Actinomycetales/classification , Peritoneal Dialysis/adverse effects , Peritonitis/microbiology , Colon, Transverse/pathology , Fatal Outcome , Female , Humans , Intestinal Perforation/diagnosis , Middle Aged , Recurrence , Shock, Septic/microbiologyABSTRACT
We studied the in vitro activity of tigecycline and 10 other commonly used antibiotics against 135 clinical isolates of non-diphtheria Corynebacterium spp. using the Etest system. Tigecycline minimum inhibitory concentrations for 50% and 90% of the organisms (MIC(50) and MIC(90) values, respectively, in mg/L) were: Corynebacterium urealyticum, 0.094 and 0.125; Corynebacterium amycolatum, 0.125 and 2; Corynebacterium jeikeium, 0.094 and 0.75; Corynebacterium coyleae, 0.064 and 0.064; Corynebacterium striatum, 0.064 and 1; Corynebacterium aurimucosum, 0.094 and 0.125; and Corynebacterium afermentans, 0.064 and 0.094. The activities of all other antimicrobials were variable, with good activity of glycopeptides, linezolid, quinupristin/dalfopristin and daptomycin and with resistance to macrolides in a high number of isolates. Tigecycline is a good alternative for the therapy of infections caused by non-diphtheria corynebacteria.
