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Eksp Klin Farmakol ; 74(6): 24-5, 2011.
Article in Russian | MEDLINE | ID: mdl-21870771

ABSTRACT

Results of estimation of the effect of a new hemicellulose-based anticoagulant drug on the reproductive function of white male rats are presented. No negative impact on the fertility and breed was observed for the drug administered in doses of 5 and 25 mg/kg. However, in a dose of 50 mg/kg, the new drug negatively affected spermatogenesis and decrease the reproductive function of male rats.


Subject(s)
Anticoagulants/administration & dosage , Polysaccharides , Reproduction/drug effects , Spermatogenesis/drug effects , Animals , Anticoagulants/adverse effects , Disease Models, Animal , Dose-Response Relationship, Drug , Female , Fertility/drug effects , Fetal Viability/drug effects , Male , Molecular Structure , Polysaccharides/administration & dosage , Polysaccharides/adverse effects , Pregnancy , Rats , Spermatozoa/drug effects , Spermatozoa/pathology
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