ABSTRACT
We compared the duration of antimicrobial effectiveness of 2 different antimicrobial catheters. The baseline activity of minocycline-rifampin catheters was greater than that of silver-platinum-carbon catheters against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecalis. The antimicrobial activity of the minocycline-rifampin catheters against these pathogens persisted for up to 12 days, while that of the silver-platinum-carbon catheters was depleted by day 10 (P < .05).
Subject(s)
Catheterization, Central Venous/instrumentation , Catheters, Indwelling/microbiology , Gram-Positive Bacteria/drug effects , Anti-Infective Agents/pharmacology , Bacterial Adhesion/drug effects , Catheterization, Central Venous/adverse effects , Gram-Positive Bacteria/growth & development , Massachusetts , Minocycline/pharmacology , Rifampin/pharmacologyABSTRACT
This report describes the safety observations following administration of a polyvalent DNA prime-protein boost HIV-1 vaccine formulated with adjuvant QS21. Local injection site reactions were the most common (65% of subjects), and included type IV delayed-type hypersensitivity (DTH) reactions at prior DNA inoculation sites in 12 of 28 (43%) subjects following protein vaccination. Systemic reactions revealed two cases of vasculitis temporally related to inoculation with recombinant Env protein+QS21 adjuvant. Questions remain regarding the cause of the vasculitis, but the unique DTH observation may have contributed to the high level of immune responses previously reported for this vaccine.