ABSTRACT
An intraoral delivery system designed to release 0.5 mg of fluoride per day was evaluated in short-term studies in primates. This fluoride-releasing device, bonded to the buccal surface of the maxillary right central incisor of each of six monkeys (Macaca fascicularis), produced marked elevations in saliva and plaque fluoride concentrations without increases in serum fluoride concentrations. No changes were observed in the plaque and gingival scores or the populations of various species of plaque bacteria.
Subject(s)
Fluorides/administration & dosage , Animals , Bacteria/isolation & purification , Delayed-Action Preparations , Dental Plaque/analysis , Dental Plaque/microbiology , Fluorides/metabolism , Fluorides/pharmacology , Gingiva/drug effects , Kinetics , Macaca fascicularis , Saliva/analysisSubject(s)
Cariostatic Agents , Fluorides, Topical/administration & dosage , Fluorides/administration & dosage , Administration, Oral , Animals , Delayed-Action Preparations , Dental Caries/etiology , Drinking , Drug Implants , Fluorides/metabolism , Fluorides/pharmacology , Fluorides, Topical/pharmacology , Rats , Rats, Inbred Strains , Skin , Streptococcus mutans/isolation & purificationABSTRACT
An intraoral fluoride releasing device designed to provide continual topical fluoride therapy for the prevention of dental caries was found to be effective in inhibiting caries in the rat model. Animals fitted with an intraoral device that released approximately 0.15 mg of fluoride per day developed 63% fewer carious enamel areas than animals receiving no treatment. Fluoridated drinking water (10 ppm) produced a 25% reduction in carious enamel areas. The fluoride-releasing device was more effective than ad libitum fluoridated drinking water in inhibiting caries on the approximal and sulcal surfaces. These results agree with the hypothesis that the continual presence of fluoride in oral fluids enhances the cariostatic effect of fluoride and, when combined with the results of earlier primate and human trials of the intraoral fluoride-releasing device, suggest that this fluoride delivery system can be developed into an effective anticaries agent.
Subject(s)
Dental Caries/prevention & control , Fluorides/administration & dosage , Animals , Delayed-Action Preparations , Evaluation Studies as Topic , Rats , Rats, Inbred Strains , Water SupplyABSTRACT
An intraoral-releasing device designed to release 0.5 mg of fluoride per day was evaluated in a one-month trial. The results showed that the 11 men who wore the fluoride-releasing device on their maxillary first molars had significantly elevated levels of fluoride in their saliva and plaque compared with baseline levels. No significant changes were observed in mean serum or urine fluoride levels or in the gingival or plaque indexes during the study. The prevalence of S mutans in whole saliva did not change during the study and the relative proportion of S. mutans, S. sanguis, and A viscosus and A naeslundii in plaque also remained relatively stable. The elevated fluoride levels in saliva and plaque are presumptive evidence that the intraoral fluoride-releasing device could exert a cariostatic effect in humans. However, long-term clinical trials are needed to determine the cariostatic potential of this fluoride releasing system.
