ABSTRACT
BACKGROUND: The purpose of the present study was to prospectively measure quality of life (QOL) before and after pulmonary resection for non-small cell lung cancer (NSCLC) and to determine which clinical perioperative variables predicted QOL. METHODS: Thirty-seven patients undergoing a curative resection for early-stage NSCLC were administered the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire serially. This was used to calculate a Trial Outcome Index (TOI), a measure of QOL. RESULTS: Perioperative variables associated with worse postoperative TOI included the presence of preoperative dyspnea (coefficient -7.89, 95% confidence interval -12.4 to -3.31, P = .01) and exposure to adjuvant chemotherapy (-14.7, -20.0 to -9.46, P = .001). CONCLUSIONS: Preoperative dyspnea and postoperative chemotherapy are associated with worse postoperative QOL among patients with resected, early-stage NSCLC. As adjuvant and neoadjuvant therapy protocols become more prevalent for these patients, QOL issues may assume greater importance.
Subject(s)
Carcinoma, Non-Small-Cell Lung/surgery , Lung Neoplasms/surgery , Pneumonectomy , Quality of Life , Bronchoscopy , Carcinoma, Non-Small-Cell Lung/diagnosis , Carcinoma, Non-Small-Cell Lung/drug therapy , Carcinoma, Non-Small-Cell Lung/mortality , Chemotherapy, Adjuvant , Comorbidity , Disease-Free Survival , Dyspnea/physiopathology , Female , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/drug therapy , Lung Neoplasms/mortality , Lung Neoplasms/physiopathology , Male , Multivariate Analysis , Postoperative Period , Prospective Studies , Recovery of Function , Respiratory Function Tests , Risk Factors , Surveys and QuestionnairesABSTRACT
A 47-year-old woman with a 20 pack-year history of cigarette smoking presented with a chest x-ray demonstrating a left upper lobe lung density. Computed tomography of the chest showed a 3-cm lobulated mass in the apical left upper lobe. The lesion demonstrated intense focal uptake on FDG-PET scanning. The patient underwent left upper lobectomy. Pathology demonstrated the histologic and immunohistochemical findings of a well differentiated fetal adenocarcinoma (WDFA). The intense FDG-PET uptake and abundant glycogen stores associated with WDFA may be the result of its embryonic derivation and differential expression of glucose transporter proteins.
Subject(s)
Adenocarcinoma/diagnostic imaging , Lung Neoplasms/diagnostic imaging , Positron-Emission Tomography , Female , Fluorodeoxyglucose F18 , Humans , Middle Aged , RadiopharmaceuticalsABSTRACT
BACKGROUND: Few studies have examined long-term outcomes in alcohol-abusing patients with lung cancer. The purpose of this study was to examine the effect of alcohol abuse on the prognosis of patients with lung cancer. METHODS: The study was composed of 114 consecutive patients with nonsmall-cell lung cancer treated at a Department of Veterans Affairs Medical Center. An alcohol-abusing group consisted of 36 patients with one of the following at the time of lung cancer diagnosis: positive screening questionnaire, alcohol consumption more than 5 drinks or cans of beer a day, or criteria for a diagnosis of alcohol dependence/abuse according to the Diagnostic and Statistical Manual for Mental Disorders IV. The comparison group consisted of 78 nonabusing patients. RESULTS: Alcohol abusers, compared with nonabusers, had worse Kaplan-Meier overall survival (median 8.5 versus 17.5 months, p = 0.05) and progression-free survival (median 6.0 versus 15.5 months, p = 0.04). In multivariate analyses including alcohol abuse, Charlson comorbidity, pack-years smoking, performance status, and stage, only stage of disease, performance status, and alcohol abuse (odds ratio = 3.44, 95% confidence interval = 1.17 to 10.1, p = 0.02) predicted progression of disease or death within 12 months of diagnosis. Alcohol abuse was also an independent predictor of disease-specific survival (hazard ratio = 1.65, 95% confidence interval = 1.01 to 2.80, p = 0.05) and progression-free survival (hazard ratio = 1.79, 95% confidence interval = 1.12 to 2.86, p = 0.01) among patients with lung cancer. CONCLUSIONS: Alcohol-abusing patients with nonsmall-cell lung cancer have worse outcomes than nonabusing patients. The adverse prognosis associated with alcohol abuse is independent of comorbidity, performance status, or smoking history.
Subject(s)
Alcoholism/mortality , Carcinoma, Non-Small-Cell Lung/mortality , Lung Neoplasms/mortality , Aged , Carcinoma, Non-Small-Cell Lung/diagnosis , Carcinoma, Non-Small-Cell Lung/therapy , Cardiovascular Diseases/mortality , Comorbidity , Confidence Intervals , Diabetes Mellitus/mortality , Disease Progression , Female , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/therapy , Male , Middle Aged , Multivariate Analysis , Neoplasm Staging , Ohio/epidemiology , Prognosis , Proportional Hazards Models , Smoking/mortality , Survival AnalysisABSTRACT
BACKGROUND: The aim of this study was to determine the surgical risks and long-term survival in alcoholic patients undergoing resection for non-small-cell lung cancer. METHODS: Nineteen resected patients comprising the alcoholic group were identified by either a Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis of alcohol dependence/abuse, or an alcohol consumption of 60 oz/d or more. Alcoholic patients were compared with 37 nonalcoholic patients undergoing resection. RESULTS: Alcoholic patients had an increase in major infectious complications (37% [7 of 19] versus 5% [2 of 37], P = 0.005), respiratory failure (42% [8 of 19] versus 5% [2 of 37], P
Subject(s)
Alcoholism/epidemiology , Carcinoma, Non-Small-Cell Lung/epidemiology , Carcinoma, Non-Small-Cell Lung/surgery , Lung Neoplasms/epidemiology , Lung Neoplasms/surgery , Postoperative Complications/mortality , Aged , Alcoholism/diagnosis , Carcinoma, Non-Small-Cell Lung/diagnosis , Case-Control Studies , Comorbidity , Female , Follow-Up Studies , Humans , Lung Neoplasms/diagnosis , Male , Middle Aged , Odds Ratio , Pneumonectomy/methods , Pneumonectomy/mortality , Probability , Proportional Hazards Models , Reference Values , Retrospective Studies , Risk Assessment , Severity of Illness Index , Survival Analysis , Time Factors , Treatment OutcomeABSTRACT
This communication provides useful information for Foreign Medical Graduates (FMGs) planning to pursue post-graduate residency training in the United States of America (USA). While the number of residency training positions is shrinking, and the number of United States graduates has steadily declined over the past decade, the number of FMGs has also steadily increased. Unfortunately, as a result of the terrorist attack of September 11, 2001, the problem of obtaining training visas and sponsorship by the Educational Commission for Foreign Medical Graduates (ECFMG) will remain major problems for FMGs. This present review is by no means exhaustive. It should serve as a guideline to more detailed and focused information. It is extremely important to network with friends, family, and professional colleagues regarding the subjective and objective aspects of pursuing graduate medical education (GME) in the USA. Though the process is very protracted and at times frustrating and depressing; the visa hurdle will be the ultimate barrier to overcome. However, majority of FMGs eventually achieve the ultimate goal of obtaining superb training and experience in the United States. We highly recommend the book by Kenneth V. Iserson entitled "Iserson's Getting Into A Residency: A Guide for Medical Students" published by Galen Press Limited, Tucson, Arizona (ref# 10). It is a very useful source of information for medical students and residents planning further residency training in the United States of America. Useful Internet addresses are listed in Appendix 1.
