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1.
J Anim Physiol Anim Nutr (Berl) ; 108(4): 978-986, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38403923

ABSTRACT

The utilization of dietary components to support gut function and the health of young animals is an important factor for improved performance. The influence of high dietary fat levels in a low or high energy density diet on the performance of weaned piglets in relation to intestinal absorptive function, amino acid utilization, oxidative stress, and microbial metabolites was assessed in this study. The study examined the effect of two different diets containing either a low energy density/high-fat level or a high energy density/high-fat level. A total of 16 healthy weaners (9.60 ± 0.13 kg) were allocated to one of the two dietary treatments. There were eight weaners per treatment. Results showed that feed intake and body weight gain of weaners were increased by the diet of high energy density/high-fat level (p < 0.05), but the feed efficiency showed an increased tendency of significance (p = 0.05). In the duodenum, the villus height (VH) and VH/crypt depth (CD) ratio (VH:CD) were increased by dietary high energy density/high fat. In the jejunum and ileum, the CD was increased by low energy density/high-fat diet, while the goblet cell count and VH:CD were increased by dietary high energy density/high-fat level. Methionine, lysine and phenylalanine concentrations were increased by high energy density/high-fat diet while low energy density/high-fat diet showed an increased tendency to increase citrulline and ornithine concentrations in the piglet. Oxidative stress marker, lactase enzyme activity and serum calcium concentration were increased by a high energy density/high-fat diet. Increased dietary fat in all diets induced diarrhoea in the weaners (p < 0.01). It was concluded that a dietary high energy density/high-fat diet seems to positively modulate gut absorptive function, serum amino acid (methionine and lysine), calcium levels and increased oxidative stress markers in the weaned piglets.


Subject(s)
Animal Feed , Animal Nutritional Physiological Phenomena , Diet , Dietary Fats , Oxidative Stress , Animals , Swine/physiology , Animal Feed/analysis , Diet/veterinary , Dietary Fats/administration & dosage , Intestines/physiology , Intestines/drug effects , Energy Intake , Male , Weaning , Amino Acids/blood , Amino Acids/metabolism
2.
J Anim Physiol Anim Nutr (Berl) ; 108(1): 81-98, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37587717

ABSTRACT

The increase in global temperature and consumers' welfare has increased the use of phytogenic feed additives (PFA) to mitigate the negative effects of heat stress on chickens in recent years. Various bioactive compounds capable of improving the thermotolerance of broiler chickens during exposure to thermal challenges have been identified in different plant species and parts. This review is an overview of the roles of bioactive compounds of different PFA, such as polyphenols and flavonoids, antioxidants, growth-promoting and immune-modulating agents, in heat stress management in broiler chickens. Common PFA in use, particularly in tropical environments, are also discussed. An understanding of the roles of the PFA in chickens' thermotolerance could further stimulate interest in their use, thereby improving the birds' productivity and addressing consumers' concerns. This review collates the existing data on the roles of herbs in mitigating heat stress on chickens and highlights future research perspectives.


Subject(s)
Biodiversity , Chickens , Animals , Temperature , Antioxidants , Animal Feed/analysis
3.
Curr Pharm Des ; 26(22): 2642-2656, 2020.
Article in English | MEDLINE | ID: mdl-32410554

ABSTRACT

BACKGROUND: Currently, daily consumption of green herb functional food or medicinal herbs has increased as adopted by many people worldwide as a way of life or even as an alternative to the use of synthetic medicines. Phytochemicals, which are a series of compounds of relatively complex structures and restricted distribution in plants, usually perform the defensive functions for plants against insects, bacteria, fungi or other pathogenic factors. A series of studies have found their effectiveness in the treatment or prevention of systemic diseases such as autoimmune diseases, cancer, neurodegenerative diseases, Crohn's disease and so on. OBJECTIVE: This review systematizes the literature on the mechanisms of the phytochemicals that react against unique free radicals and prevent the oxidative stress and also summarizes their role in gut microbiota inhibiting bacterial translocation and damage to the intestinal barrier and improving the intestinal membrane condition. CONCLUSION: The gut microbiota modulation and antioxidant activities of the phytochemicals shall be emphasized on the research of the active principles of the phytochemicals.


Subject(s)
Gastrointestinal Microbiome , Plants, Medicinal , Humans , Intestines , Oxidative Stress , Phytochemicals/pharmacology
4.
Pharmacol Res ; 152: 104629, 2020 02.
Article in English | MEDLINE | ID: mdl-31918019

ABSTRACT

Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction of free radicals where oxidative stress could contribute it. Possible factors are defective insulin signals, glucose oxidation, and degradation of glycated proteins as well as alteration in glutathione metabolism which induced hyperglycemia. Previous studies revealed a link between T2DM with oxidative stress, inflammation and insulin resistance which are assumed to be regulated by numerous cellular networks such as NF-κB, PI3K/Akt, MAPK, GSK3 and PPARγ. Flavonoids are ubiquitously present in the nature and classified according to their chemical structures for example, flavonols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones. Flavonoids indicate poor bioavailability which could be improved by employing various nano-delivery systems against the occurrences of T2DM. These bioactive compounds exert versatile anti-diabetic activities via modulating targeted cellular signaling networks, thereby, improving glucose metabolism, α -glycosidase, and glucose transport or aldose reductase by carbohydrate metabolic pathway in pancreatic ß-cells, hepatocytes, adipocytes and skeletal myofibres. Moreover, anti-diabetic properties of flavonoids also encounter diabetic related complications. This review article has designed to shed light on the anti-diabetic potential of flavonoids, contribution of oxidative stress, evidence of efficacy in clinical, cellular and animal studies and nano-delivery approaches to enhance their therapeutic efficacy. This article might give some new insights for therapeutic intervention against T2DM in near future.


Subject(s)
Diabetes Mellitus, Type 2/drug therapy , Flavonoids/therapeutic use , Hypoglycemic Agents/therapeutic use , Animals , Drug Delivery Systems , Flavonoids/pharmacology , Humans , Hypoglycemic Agents/pharmacology , Nanotechnology , Oxidative Stress/drug effects , Treatment Outcome
5.
Arch Anim Nutr ; 74(1): 39-56, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31552757

ABSTRACT

The aim of the study was to investigate the effects of dietary alpha-ketoglutarate (AKG) on the faecal bacteria composition of suckling piglets after supplementation of AKG to the diet of lactating sows. After farrowing, the sows were assigned to either a normal lactation diet (control group, n = 12) or a diet supplemented with 0.25% AKG (AKG group, n = 12) based on body weight (BW) and parity. During the 21-d suckling period, BW and diarrhoea occurrences of piglets were recorded daily, while faeces were sampled weekly from sows and piglets. The levels of pH, ammonia, short-chain fatty acids (SCFA) and lactate in the faeces of piglets were determined. In particular, bacteria profiles in faeces of sows and their suckling piglets were examined by Illumina sequencing. The results showed that the AKG diet altered the faecal bacteria composition in sows during the 21-d lactation period, leading to increases (p < 0.05) in the abundances of genera Prevotella, Lactobacillus, Bacteroides and Methanobrevibacter, but decreases (p < 0.05) in the abundances of genera Oscillospira and Dorea. AKG supplement to the sows during lactation indirectly enhanced (p < 0.05) bacterial richness and SCFA levels (especially, acetate) in the faeces of piglets during the 21-d suckling period. It is suggested that maternal AKG supplementation alters the composition of faecal bacteria in the sows, and increases the faecal bacteria richness and acetate levels in the piglets, which might be associated with an enhanced growth performance of piglets.


Subject(s)
Feces/microbiology , Ketoglutaric Acids/metabolism , Sus scrofa/microbiology , Animal Feed/analysis , Animals , Animals, Newborn , Diet/veterinary , Dietary Supplements/analysis , Dose-Response Relationship, Drug , Female , Ketoglutaric Acids/administration & dosage , Lactation , Random Allocation , Sus scrofa/metabolism
6.
Trop Anim Health Prod ; 52(3): 1459-1466, 2020 May.
Article in English | MEDLINE | ID: mdl-31845116

ABSTRACT

Camels (Camelus dromedarius) have access to different browsing plant that is a major source of feed and therapeutic value but also has the potential to cause poisoning to the camel. A survey was conducted between July and September 2017 to generate information on medicinal uses, toxicity, and chemical composition of major browsing plant in the Somali Regional State of Ethiopia. A total of 150 respondents were interviewed using a structured questionnaire, and supplementary information was gathered through field observation and focus group discussions. The study showed 13 medicinal plants as being used by the respondents for the treatment of various camel ailments. The common part of the plant used to treat various aliment was leaves followed by root and bark. Dermal was the preferred route of remedy application followed by oral. The respondents identified 10 major toxic browsing plants. Those plants affect camels mainly in the dry and early rainy seasons when feed supply is scarce. Yet, poisonous browsing plants were the bottleneck problem and a major cause of economic loss in camel production in all study districts despite controlling poisonous plants through the indigenous approach. In total, 12 browse plants relished by camels were subjected to the chemical composition analysis. Laboratory result shown the chemical composition of browsing plants relished by camels has disparity except for the dry matter, and they have moderate crude protein content. Hence, the present study implies that the identified medicinal and preferred browsing plants have a significant contribution in supporting camel production in the pastoral area, but the emphasis should be given to reduce/eradicate poisonous plants that cause acute illness and death of camel.


Subject(s)
Animal Feed , Camelus/physiology , Phytotherapy , Plant Leaves/chemistry , Plants, Medicinal , Seasons , Adult , Animals , Ethiopia , Female , Focus Groups , Humans , Male , Medicine, Traditional , Middle Aged , Phytochemicals , Young Adult
7.
Arch Anim Nutr ; 73(6): 457-471, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31454268

ABSTRACT

The aim of the study was to investigate if dietary alpha-ketoglutarate (AKG) supplementation may improve the performance of lactating sows and their suckling piglets. After farrowing, 24 lactating sows (Large White × Landrace) with similar body weight (BW) were assigned to the control and AKG groups based on parity, and their lactation diets were supplemented with 0.00 or 0.25% AKG, respectively. It was found that supplementing the diet of lactating sows with 0.25% AKG enhanced growth performance of the suckling piglets from d 7 to d 21 of the lactation period, improved villus height of ileum and tended (p = 0.085) to increase mean volumetric bone mineral density of femur in the weanling piglets. In the lactating sows, dietary supplementation of AKG decreased plasma urea level on d 14 of lactation, decreased plasma calcium (Ca) concentrations from d 7 to d 21 of lactation and increased lactose and Ca levels in ordinary milk. Thus, it was proposed that AKG supplementation stimulates the capacity for lactose synthesis and Ca uptake in the mammary gland, thereby altering the composition of the ordinary milk which might be associated with the enhanced performance of piglets during the suckling period. These findings could lead to a better application of AKG in lactating nutrition, and therefore, promoting pork production.


Subject(s)
Amino Acids/metabolism , Animals, Suckling/growth & development , Ketoglutaric Acids/metabolism , Lactation/drug effects , Protein Biosynthesis , Sus scrofa/physiology , Amino Acids/drug effects , Animal Feed/analysis , Animals , Animals, Suckling/metabolism , Diet/veterinary , Dietary Supplements/analysis , Female , Ketoglutaric Acids/administration & dosage , Mammary Glands, Animal/drug effects , Mammary Glands, Animal/physiology , Milk/chemistry , Nutritive Value/drug effects , Protein Biosynthesis/drug effects , Sus scrofa/growth & development
8.
J Anim Physiol Anim Nutr (Berl) ; 103(5): 1492-1502, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31106906

ABSTRACT

This study evaluated the effect of high or low digestible energy ratio of carbohydrate in a high or normal dietary energy density on performance, amino acid utilization and intestinal functions of weaned piglets. A total of 32 healthy weaners (9.60 ± 0.13 kg) were allocated to two dietary energy densities (3,400 and 3,800 kcal/kg) and two digestible energy ratio of carbohydrate to fat (9:1 and 3:1) in a 2 × 2 factorial arrangement. There were eight piglets per treatment. The feed intake of piglets was significantly increased by dietary high carbohydrate ratio (9:1) (p < 0.01); however, this did not result in improved body weight gain (p > 0.05). The piglets fed high carbohydrate energy ratio had a reduced villus height/crypt depth (VH/CD) ratio in the duodenum (p < 0.05), and dietary high energy density further decreased the VH/CD ratio in the ileum (p < 0.01). In the duodenum, the lymphocyte count was increased by dietary high energy density (p < 0.05), while dietary energy density and carbohydrate energy ratio interacted to increase lymphocyte count in the ileum (p < 0.05). The serum cholesterol, triglyceride and low-density lipoprotein were not significantly affected (p > 0.05), but dietary energy density interacted with dietary energy ratio to increase high-density lipoprotein concentration (p < 0.05) in piglets fed reduced carbohydrate energy ratio. Dietary high energy density reduced energy digestibility (p < 0.05), whereas high carbohydrate energy ratio increased crude protein digestibility in the piglets (p < 0.05). The intestinal sucrase, lactase activities and serum concentrations of histidine, leucine, lysine, methionine, phenylalanine, alanine, glycine, tyrosine and citrulline were higher in the piglets fed dietary increased carbohydrate energy ratio. Oxidative stress markers and volatile fatty acids concentrations were altered by the dietary treatments. It was concluded that dietary high energy density could be detrimental to piglets intestinal functions and that increased carbohydrate energy ratio could affect amino acid utilization and body weight gain in weaner pigs.


Subject(s)
Amino Acids/metabolism , Animal Feed/analysis , Diet/veterinary , Dietary Carbohydrates/administration & dosage , Energy Intake , Swine , Animal Nutritional Physiological Phenomena , Animals , Digestion/drug effects , Fatty Acids, Volatile/chemistry , Gastrointestinal Contents/chemistry , Hydrogen-Ion Concentration , Intestines/anatomy & histology , Intestines/drug effects , Nutrients/metabolism
9.
J Poult Sci ; 56(2): 112-119, 2019 Apr 25.
Article in English | MEDLINE | ID: mdl-32055205

ABSTRACT

The growth performance, nutrient digestibility, hematology, serum chemistry, and lipoprotein concentrations of turkey (Meleagris gallopavo) poults fed diets supplemented with high or recommended concentrations of niacin were investigated in this study. A total of 120 four-week-old turkey poults were randomly divided into three treatment groups with five replicates of eight birds in each group. The poult diets were supplemented with 0.0, 60, and 180 mg/kg niacin in the three treatments, termed control, recommended niacin supplementation (RNS), and high niacin supplementation (HNS), respectively. The study lasted for four weeks. The results showed that the HNS treatment reduced the feed intake and increased the body weight gain of poults. The apparent, nitrogen-corrected, and true metabolizable energy contents were the highest in the HNS-group turkey poults (P<0.05). The red and white blood cell counts and hemoglobin concentration of the turkeys improved with increasing niacin supplementation (P<0.01). The serum constituents, including the serum protein and globulin, were significantly increased (P<0.05), while the uric acid and creatinine contents were significantly reduced in the HNS-group turkeys. Similarly, the HNS-group turkeys exhibited significantly reduced alanine aminotransferase (ALT) and alkaline phosphatase (ALP) contents, while the RNS-group turkeys had the least aspartate aminotransferase (AST) content. In addition, the HNS-group turkeys had the least serum low-density lipoprotein (LDL), triglyceride, and total cholesterol concentrations and the highest serum high-density lipoprotein (HDL) (P<0.01) concentrations. In conclusion, the supplementation of 180 mg/kg niacin in the diet reduced the feed intake and serum ALT, ALP, LDL, triglyceride, and cholesterol contents and increased the body weight gain, metabolizable energy, and HDL concentration in turkeys. This study showed that niacin supplementation could reduce the fat content without compromising the body weight gain and increase stress resistance in turkey poults.

10.
Anim Nutr ; 5(4): 331-339, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31890909

ABSTRACT

Type, quality, and origin of cereals in diets of poultry and pigs could influence gut microbes and affect their diversity and function, thereby impacting the intestinal function of the monogastric animal. In this review, we focus on the major carbohydrates in cereals that interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids (SCFA), and discuss how cereal fiber impact intestinal health of poultry and pigs. An overview of how the cereals and cereals-derived carbohydrates such as beta-glucans, resistant starch, cellulose, and arabinoxylans could promote intestinal health and reduce the use of in-feed antibiotics in animal production are presented. The metabolic pathway utilized by microbes and the mechanism of action underlying the produced SCFA on intestinal health of monogastric animals is also discussed.

12.
Biomed Res Int ; 2016: 2912418, 2016.
Article in English | MEDLINE | ID: mdl-27366740

ABSTRACT

Tryptophan (Trp) plays an essential role in pig behavior and growth performances. However, little is known about Trp's effects on tight junction barrier and intestinal health in weaned pigs. In the present study, twenty-four (24) weaned pigs were randomly assigned to one of the three treatments with 8 piglets/treatments. The piglets were fed different amounts of L-tryptophan (L-Trp) as follows: 0.0%, 0.15, and 0.75%, respectively, named zero Trp (ZTS), low Trp (LTS), and high Trp (HTS), respectively. No significant differences were observed in average daily gain (ADG), average daily feed intake (ADFI), and gain: feed (G/F) ratio between the groups. After 21 days of the feeding trial, results showed that dietary Trp significantly increased (P < 0.05) crypt depth and significantly decreased (P < 0.05) villus height to crypt depth ratio (VH/CD) in the jejunum of pig fed HTS. In addition, pig fed HTS had higher (P < 0.05) serum diamine oxidase (DAO) and D-lactate. Furthermore, pig fed HTS significantly decreased mRNA expression of tight junction proteins occludin and ZO-1 but not claudin-1 in the jejunum. The number of intraepithelial lymphocytes and goblet cells were not significantly different (P > 0.05) between the groups. Collectively, these data suggest that dietary Trp supplementation at a certain level (0.75%) may negatively affect the small intestinal structure in weaned pig.


Subject(s)
Dietary Supplements , Intestines/anatomy & histology , Tight Junction Proteins/metabolism , Tryptophan/pharmacology , Weaning , Amine Oxidase (Copper-Containing)/blood , Amino Acids, Neutral/blood , Animals , Growth and Development/drug effects , Intestines/drug effects , Jejunum/drug effects , Jejunum/metabolism , RNA, Messenger/genetics , RNA, Messenger/metabolism , Sus scrofa
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