ABSTRACT
We present a case of bone marrow granulomas in a 64-year-old West Indian man who presented with severe leucopenia, anaemia, thrombocytopenia, hepatosplenomegaly, hypercalcaemia, hypercalciuria, elevated angiotensin converting enzyme level and reticulo-nodular shadows on chest X-ray. Bone marrow biopsy revealed numerous non-caseating epithelioid granulomas. A diagnosis of sarcoidosis was made and he was treated with prednisolone 60 mg daily for four weeks and the dose was subsequently reduced to 30 mg daily. Eight months follow-up revealed persistent pancytopenia. Bone marrow granulomas are rare and, when they occur, sarcoidosis is an uncommon aetiology. This case illustrates that severe leucopenia may occur in sarcoidosis and may present therapeutic difficulties.
Subject(s)
Bone Marrow Diseases/diagnosis , Leukopenia/diagnosis , Sarcoidosis/diagnosis , Biopsy , Bone Marrow/pathology , Bone Marrow Diseases/pathology , Granuloma/diagnosis , Granuloma/pathology , Humans , Leukopenia/pathology , Male , Middle Aged , Sarcoidosis/pathology , Severity of Illness IndexABSTRACT
We present a case of bone marrow granulomas in a 64-year-old West Indian man who presented with severe leucopenia, anaemia, thrombocytopenia, hepatosplenomegaly, hypercalcaemia, hypercalciuria, elevated angiotensin converting enzyme level and reticulo-nodular shadows on chest X-ray. Bone marrow biopsy revealed numerous non-caseating epithelioid granulomas. A diagnosis of sarcoidosis was made and he was treated with prednisolone 60 mg daily for four weeks and the dose was subsequently reduced to 30 mg daily. Eight months follow-up revealed persistent pancytopenia. Bone marrow granulomas are rare and, when they occur, sarcoidosis is an uncommon aetiology. This case illustrates that severe leucopenia may occur in sarcoidosis and may present therapeutic difficulties
Subject(s)
Humans , Male , Middle Aged , Bone Marrow Diseases/diagnosis , Leukopenia/diagnosis , Sarcoidosis/diagnosis , Biopsy , Bone Marrow Diseases/pathology , Granuloma/diagnosis , Granuloma/pathology , Leukopenia/pathology , Bone Marrow/pathology , Sarcoidosis/pathology , Severity of Illness IndexSubject(s)
Cryptococcosis/diagnosis , HTLV-I Infections/diagnosis , Human T-lymphotropic virus 1/isolation & purification , Lung Diseases, Fungal/diagnosis , Opportunistic Infections/diagnosis , Adult , Antifungal Agents/administration & dosage , Antiviral Agents/administration & dosage , Biopsy, Needle , Cryptococcosis/complications , Cryptococcosis/immunology , Drug Therapy, Combination , Female , HTLV-I Infections/complications , HTLV-I Infections/immunology , Humans , Immunocompromised Host , Immunohistochemistry , Lung Diseases, Fungal/complications , Lung Diseases, Fungal/immunology , Opportunistic Infections/complications , Opportunistic Infections/immunology , Prognosis , Risk Assessment , Severity of Illness IndexABSTRACT
A case of fatal strongyloidiasis associated with human T-cell lymphotropic virus type 1 (HTLV-1) infection is described in a 45-year-old West Indian man living in an area endemic for both strongyloidiasis and HTLV-1 infection. Clinical presentation was typical with severe diarrhea, vomiting, and progressive weight loss. Stool microscopy revealed Strongyloides stercoralis rhabditiform larvae. Despite treatment with thiabendazole, the patient died. Autopsy findings revealed severe ileocolitis due to Strongyloides larvae, right subdiaphragmatic pyogenic abscess, and severe pleuritis of the right lower lobe of the lung. This case illustrates that despite effective antihelmintic therapy, mortality is still high in patients with the hyperinfective state of S. stercoralis. Thus, in patients in areas endemic for both Strongyloides infection and HTLV-1, or in immigrants from these areas, repeated stool microscopy is indicated in patients positive for HTLV-1.
Subject(s)
HTLV-I Infections/complications , Strongyloidiasis/etiology , Fatal Outcome , HTLV-I Infections/immunology , Humans , Immune Tolerance , Male , Middle AgedABSTRACT
We describe a case of Kaposi's sarcoma in a previously healthy 35-year-old bisexual West Indian man of African descent who was seronegative for the human immunodeficiency virus (HIV) and human T-cell lymphotropic virus-1 (HTLV-1) and who presented with extensive mucocutaneous lesions, weight loss, visceral and generalized lymph node involvement, poor response to combination therapy with vinblastine and interferon alfa-2a, and a short survival of eight months from the onset of illness. This is the first documented case of Kaposi's sarcoma in Dominica. The presentation is unusual in that it is similar to the aggressive and disseminated Kaposi's sarcoma seen only in AIDS and the florid variant of the endemic disease in young men in Equatorial Africa.
Subject(s)
HIV Seronegativity , Sarcoma, Kaposi/diagnosis , Skin Neoplasms/diagnosis , Adult , Antineoplastic Agents, Phytogenic/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Fatal Outcome , Humans , Interferon alpha-2 , Interferon-alpha/therapeutic use , Male , Recombinant Proteins , Sarcoma, Kaposi/drug therapy , Skin Neoplasms/drug therapy , Vinblastine/therapeutic useABSTRACT
We describe a case of Kaposi's sarcoma in a previously healthy 35-year-old bisexual West Indian man of African descent who was seronegative for the human immunodeficiency virus (HIV) and human T-cell lymphotropic virus-1 (HTLV-1) and who presented with extensive mucocutaneous lesions, weight loss, visceral and generalized lymph node involvement, poor response to combination therapy with vinblastine and interferon alfa-2a, and a short survival of eight months from the onset of illness. This is the first documented case of Kaposi's sarcoma in Dominica. The presentation is unusual in that it is similar to the aggressive and disseminated Kaposi's sarcoma seen only in AIDS and the florid variant of the endemic disease in young men in Equatorial Africa.
Subject(s)
Adult , Humans , Male , Sarcoma, Kaposi , HIV Seronegativity , Skin Neoplasms/diagnosis , Sarcoma, Kaposi , Vinblastine , Interferon-alpha , Antineoplastic Agents, Phytogenic/therapeutic use , Fatal Outcome , Skin Neoplasms/drug therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic useABSTRACT
We describe a case of Kaposi's sarcoma in a previously healthy 35-year-old bisexual West Indian man of African descent who was seronegative for the human immunodeficiency virus (HIV) and human T-cell lymphotropic virus-1 (HTLV-1) and who presented with extensive mucocutaneous lesions, weight loss, visceral and generalized lymph node involvement, poor response to combination therapy with vinblastine and inter feron alfa-2a and a short survival of eight months from onset of illness. This is the first document case of Kaposi's sarcoma in Domonica. The presentation is unusal in that it is similar to the aggressive and disseminated Kaposi's sarcoma seen only in AIDS and florid variant of the endemic disease in young men in Equatorial Africa. (AU)
