ABSTRACT
OBJECTIVES: Bitter taste perception affects food preference, eating behavior, and nutrient intake. The purpose of this study was to investigate the contribution of bitter taste gene polymorphisms to body fatness as measured by percentage of body fat. METHOD: Three common single nucleotide polymorphisms (SNPs) of the TAS2R38 gene which result in amino acid changes in the protein (A49P, V262A, and I296V), were studied in three racially diverse groups: European Americans n = 313, African Americans n = 109, and Asians n = 234. RESULTS: The allele frequencies of the three SNPs were similar to previous studies. The rare haplotypes, AAI and AAV, were found in high prevalence in the African American subgroup (22.94%) and European American subgroup (6.07%). The PROP non taster; AVI/AVI diplotype was associated with a higher risk of obesity in European American and Asian but not African American subjects after age adjustment. CONCLUSIONS: TAS2R38 polymorphisms could be associated with obesity development. In addition to taste perception, nutrient sensing and energy metabolism should be studied in relation to bitter taste receptors to confirm the association between genetic polymorphisms and body fatness. Genetic polymorphisms, race, gender, and environmental factors such as dietary patterns could all contribute to body fat.
ABSTRACT
Data enabled research with a spatial perspective may help to combat human diseases in an informed and cost-effective manner. Understanding the changing patterns of environmental degradation is essential to help in determining the health outcomes such as asthma of a community. In this research, Mississippi asthma-related prevalence data for 2003-2011 were analyzed using spatial statistical techniques in Geographic Information Systems. Geocoding by ZIP code, choropleth mapping, and hotspot analysis techniques were applied to map the spatial data. Disease rates were calculated for every ZIP code region from 2009 to 2011. The highest rates (4-5.5%) were found in Prairie in Monroe County for three consecutive years. Statistically significant hotspots were observed in urban regions of Jackson and Gulf port with steady increase near urban Jackson and the area between Jackson and meridian metropolis. For 2009-2011, spatial signatures of urban risk factors were found in dense population areas, which was confirmed from regression analysis of asthma patients with population data (linear increase of R2 = 0.648, as it reaches a population size of 3,5000 per ZIP code and the relationship decreased to 59% as the population size increased above 3,5000 to a maximum of 4,7000 per ZIP code). The observed correlation coefficient (r) between monthly mean O3 and asthma prevalence was moderately positive during 2009-2011 (r = 0.57). The regression model also indicated that 2011 annual PM2.5 has a statistically significant influence on the aggravation of the asthma cases (adjusted R-squared 0.93) and the 2011 PM2.5 depended on asthma per capita and poverty rate as well. The present study indicates that Jackson urban area and coastal Mississippi are to be observed for disease prevalence in future. The current results and GIS disease maps may be used by federal and state health authorities to identify at-risk populations and health advisory.
