1.
Chirality
; 5(7): 554-9, 1993.
Article
in English
| MEDLINE
| ID: mdl-7902121
ABSTRACT
The enantiomeric purities of optically active intermediates for beta-adrenergic blocking agents prepared via enzyme-assisted processes can be determined rapidly and with high accuracy using HPLC on commercially available columns with chiral supports [Chiralcel OD, OB; Chiralpak OT(+)]. The dependence of the resolution parameters on the substitution pattern of both hydroxy compounds and their esters is reported.