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2.
Vopr Onkol ; 26(1): 41-6, 1980.
Article in Russian | MEDLINE | ID: mdl-7355595

ABSTRACT

Studies on some morphological features of the squamous epithelium of esophageal mucosa in dysplastic processes and cancer in situ as well as quantitative studies of the DNA content have shown that changes in the DNA content, increased polyploidy and genetic heterogenicity of the cell elements correspond to the degree of epithelial cells dedifferentiation and might be taken into account in diagnosis of early malignification of esophageal squamous epithelium.


Subject(s)
Carcinoma in Situ/pathology , Esophageal Neoplasms/pathology , Precancerous Conditions/pathology , Biopsy , DNA, Neoplasm/analysis , Epithelium/pathology , Esophagus/pathology , Humans , Mucous Membrane/pathology , Photometry
3.
Arkh Patol ; 40(10): 40-4, 1978.
Article in Russian | MEDLINE | ID: mdl-736811

ABSTRACT

Morphological, cytophotometrical, and histochemical study of reserve cells of the excretory ducts of esophageal mucous glands in chronic esophagitis was done on autopsy material (189 cases). Chronic esophagites were found to be accompaned by diverse morphological changes of reserve cells manifested in the development of their focal and diffuse hyperplasia. The reserve cells of the esophageal epithelium were found to be capable to differentiate into the squamous and glandular epithelium. Chronic esophagites were shown to cause metabolic disorders in the nuclei of the reserve cells leading to changes in the chromosome set. In the opinion of the authors, their results are important for the elucidation of the nature of esophageal adenoacanthomas.


Subject(s)
Esophagitis/pathology , Exocrine Glands/pathology , Precancerous Conditions/pathology , Adenocarcinoma/etiology , Adult , Chronic Disease , Esophageal Neoplasms/etiology , Female , Humans , Hyperplasia , Male , Middle Aged , Mucous Membrane/pathology
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