ABSTRACT
PURPOSE: To determine the metabolic characterization of a large solitary demyelinating lesion. METHODS: Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion. RESULTS: The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study. CONCLUSION: The report summarizes the metabolic characteristics of a demyelinating plaque.
Subject(s)
Brain/diagnostic imaging , Brain/metabolism , Demyelinating Diseases/diagnostic imaging , Multiple Sclerosis/diagnostic imaging , Multiple Sclerosis/metabolism , Adult , Brain/pathology , Brain Neoplasms/pathology , Demyelinating Diseases/pathology , Diagnosis, Differential , Female , Fluorodeoxyglucose F18 , Humans , Magnetic Resonance Spectroscopy , Methionine , Multiple Sclerosis/pathology , Positron-Emission Tomography , RadiographyABSTRACT
We describe functional imaging findings using MRI, 1H-Magnetic resonance spectroscopy and positron emission tomography in a case of radiation-induced medulloblastoma following radiotherapy for pineal gland tumor. MRS showed a prominent choline peak; FDG, 11C-Met and 11C-Choline PET showed a minimal glucose, increased methionine and choline uptake.
