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1.
Acta Crystallogr Sect E Struct Rep Online ; 65(Pt 11): o2880, 2009 Oct 28.
Article in English | MEDLINE | ID: mdl-21578466

ABSTRACT

In the structure of the title compound, C(12)H(14)N(2)O(3), the piperidine ring adopts a chair conformation and the aryl substitutent occupies an equatorial position.

2.
Nucleosides Nucleotides Nucleic Acids ; 19(4): 735-48, 2000 Apr.
Article in English | MEDLINE | ID: mdl-10960032

ABSTRACT

The synthesis of 3'-O2-(azaheterocycle)-thymidines is presented from 1-thia-3-aza- 1,3-butadiene precursors (N-thioacylamidines). A variety of heterocycles is accessible using the dienic, the electrophilic or the nucleophilic reactivity of these thia-azabutadiene systems. 3'-O2-(azaheterocycle)-thymidine analogues are regarded as potential substrates to interfere with the DNA-polymerization process.


Subject(s)
Aza Compounds/chemical synthesis , Thymidine/analogs & derivatives , Thymidine/chemical synthesis , Anti-HIV Agents/pharmacology , Aza Compounds/pharmacology , Cells, Cultured/drug effects , Cytotoxicity Tests, Immunologic , HIV-1/drug effects , Lymphocytes/drug effects , Magnetic Resonance Spectroscopy , RNA-Directed DNA Polymerase/adverse effects , Thymidine/pharmacology
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