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1.

2016: Signaling Breakthroughs of the Year.

Adler, Elizabeth M.

Sci Signal ; 10(460)2017 01 03.

Article in English | MEDLINE | ID: mdl-28049765

ABSTRACT

Signaling breakthroughs of 2016 clustered mainly in the areas of neuroscience, immunology, and metabolism, with excursions into plant hormone signaling and bacterial manipulation of host signaling pathways. Perhaps reflecting the growing maturity of the discipline of cell signaling, many of this year's breakthroughs have implications for the pathogenesis or treatment of human disease.

Subject(s)

Macrophages/metabolism , Receptors, Cell Surface/metabolism , Signal Transduction , T-Lymphocytes/metabolism , Humans , Models, Biological , Protein Binding

2.

2015: Signaling Breakthroughs of the Year.

Adler, Elizabeth M.

Sci Signal ; 9(409): eg1, 2016 Jan 05.

Article in English | MEDLINE | ID: mdl-26732760

ABSTRACT

This year's signaling breakthroughs highlight insights into the pathogenesis or treatment of cancer, malaria, and neurodegenerative disorders; reveal molecular insights into cell death; and identify signals that could be leveraged to prevent plant parasitism or engineer bacteria as microbial fuel cells.

Subject(s)

Biomedical Research/methods , Biomedical Research/standards , Signal Transduction , Antimalarials/therapeutic use , Artemisinins/therapeutic use , Biomedical Research/trends , Exosomes/physiology , Host-Pathogen Interactions , Humans , Malaria, Falciparum/drug therapy , Malaria, Falciparum/parasitology , Malaria, Falciparum/physiopathology , Neoplasms/physiopathology , Neoplasms/therapy , Plant Diseases/microbiology , Plant Diseases/prevention & control , Plant Weeds/physiology , Plants/immunology , Plants/microbiology , Plasmodium falciparum/drug effects , Plasmodium falciparum/physiology , Pseudomonas aeruginosa/immunology , Pseudomonas aeruginosa/physiology , Striga/physiology

3.

Of quirky channels and a fond farewell.

Adler, Elizabeth M.

J Gen Physiol ; 146(5): 341-2, 2015 Nov.

Article in English | MEDLINE | ID: mdl-26503717

Subject(s)

Ion Channels/chemistry , Amino Acid Sequence , Animals , Humans , Ion Channels/genetics , Ion Channels/metabolism , Molecular Sequence Data , Periodicals as Topic

4.

Of ghrelin, cone cultivation, dinoflagellate eyes, and the cyanobacterial circadian clock.

Adler, Elizabeth M.

J Gen Physiol ; 146(3): 193-4, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26324673

Subject(s)

Calcium Signaling/physiology , Circadian Clocks/physiology , Cyanobacteria/physiology , Dinoflagellida/physiology , Ghrelin/metabolism , Retinal Cone Photoreceptor Cells/physiology , Humans , Receptors, Ghrelin/metabolism , Synaptic Transmission/physiology

5.

Of ATPase activity, cellular energy distribution, and linking depolarization and division.

Adler, Elizabeth M.

J Gen Physiol ; 146(4): 265-6, 2015 Oct.

Article in English | MEDLINE | ID: mdl-26415567

Subject(s)

Action Potentials , Adenosine Triphosphatases/metabolism , Energy Metabolism , Animals , Humans

6.

Of bipolar cell synapses, light-activated K+ channels, and substrate binding to DAT.

Adler, Elizabeth M.

J Gen Physiol ; 146(1): 1-2, 2015 Jul.

Article in English | MEDLINE | ID: mdl-26123193

Subject(s)

Biological Transport/physiology , Microtubules/physiology , Mitochondria/physiology , Presynaptic Terminals/physiology , Retina/physiology , Synaptic Vesicles/physiology , Animals

7.

Of BK regulation, painful connections, and versatile neuropeptide signaling.

Adler, Elizabeth M.

J Gen Physiol ; 145(6): 457-8, 2015 Jun.

Article in English | MEDLINE | ID: mdl-26009540

Subject(s)

Cell Membrane/metabolism , Ion Channel Gating , Large-Conductance Calcium-Activated Potassium Channel alpha Subunits/metabolism , Membrane Proteins/metabolism , Neoplasm Proteins/metabolism , Potassium/metabolism , Humans

8.

Of muscle modulation and the CFTR gate.

Adler, Elizabeth M.

J Gen Physiol ; 145(4): 255, 2015 Apr.

Article in English | MEDLINE | ID: mdl-25825167

Subject(s)

Calcium Channels, L-Type/metabolism , Calcium Signaling , Muscle Fibers, Skeletal/metabolism , Phosphoric Monoester Hydrolases/metabolism , Animals

9.

Thinking of calcium and fleeing flies.

Adler, Elizabeth M.

J Gen Physiol ; 145(5): 359-60, 2015 May.

Article in English | MEDLINE | ID: mdl-25918355

Subject(s)

Calcium Channels/metabolism , Excitation Contraction Coupling , Animals , Drosophila/metabolism , Drosophila/physiology

10.

Of capturing fish, mobilizing enzymes, and a surprising source for serotonin.

Adler, Elizabeth M.

J Gen Physiol ; 145(3): 165-6, 2015 Mar.

Article in English | MEDLINE | ID: mdl-25712014

Subject(s)

Serotonin/metabolism , Signal Transduction , Animals , Zebrafish

11.

Of transporter design, screening for gating modifiers, and how TRAAK gates.

Adler, Elizabeth M.

J Gen Physiol ; 145(2): 91-2, 2015 Feb.

Article in English | MEDLINE | ID: mdl-25624447

Subject(s)

Ion Channel Gating , Potassium Channels/metabolism , Voltage-Gated Sodium Channels/metabolism , Animals , Humans , Potassium Channels/chemistry , Potassium Channels/drug effects , Voltage-Gated Sodium Channels/chemistry , Voltage-Gated Sodium Channels/drug effects

12.

Of ELIC and evolution.

Adler, Elizabeth M.

J Gen Physiol ; 145(1): 1-2, 2015 Jan.

Article in English | MEDLINE | ID: mdl-25548134

Subject(s)

Evolution, Molecular , Ion Channels/metabolism , Animals , Humans , Ion Channels/chemistry , Ion Channels/genetics

13.

Of tracking channel activity, modulating AMPA receptor function, permeating potassium ions, and the plant response to osmotic stress.

Adler, Elizabeth M.

J Gen Physiol ; 144(6): 491-3, 2014 Dec.

Article in English | MEDLINE | ID: mdl-25422500

Subject(s)

Arabidopsis/physiology , Cell Membrane Permeability/physiology , Glutamic Acid/metabolism , Ion Channel Gating/physiology , Potassium/metabolism , Receptors, AMPA/metabolism , Stress, Physiological/physiology , Animals , Humans , Osmoregulation/physiology

14.

Of BK regulation, repurposed taste receptors, and arrestin recruitment.

Adler, Elizabeth M.

J Gen Physiol ; 144(4): 273-4, 2014 Oct.

Article in English | MEDLINE | ID: mdl-25267912

Subject(s)

Arrestins/physiology , Large-Conductance Calcium-Activated Potassium Channels/physiology , Sensory Receptor Cells/physiology , Taste/physiology , Animals , Humans

15.

Of transmission at unconventional synapses.

Adler, Elizabeth M.

J Gen Physiol ; 144(5): 349-50, 2014 Nov.

Article in English | MEDLINE | ID: mdl-25348410

Subject(s)

Synapses/metabolism , Synaptic Transmission , Animals , Humans , Synapses/physiology

16.

Of lipid transfer, resistance to Fâ», and stimulus-dependent channel conformations.

Adler, Elizabeth M.

J Gen Physiol ; 144(3): 205-6, 2014 Sep.

Article in English | MEDLINE | ID: mdl-25156115

Subject(s)

Ion Channel Gating , Ion Channels/metabolism , Animals , Humans , Ion Channels/chemistry

17.

Taking a thermodynamic approach: a conversation with Baron Chanda.

Chanda, Baron; Adler, Elizabeth M.

J Gen Physiol ; 144(2): 127, 2014 Aug.

Article in English | MEDLINE | ID: mdl-25070430

Subject(s)

Physiology/trends , Thermodynamics , Congresses as Topic

18.

Of cytokine receptor scissors, grasping bacterial hands, and movement across the blood-brain barrier.

Adler, Elizabeth M.

J Gen Physiol ; 144(1): 5-6, 2014 Jul.

Article in English | MEDLINE | ID: mdl-24981227

Subject(s)

Blood-Brain Barrier/metabolism , Receptors, Cytokine/metabolism , Transcytosis/physiology , Animals , Humans , Membrane Transport Proteins/chemistry , Membrane Transport Proteins/metabolism , Protein Structure, Secondary , Protein Structure, Tertiary , Protein Transport/physiology , Receptors, Cytokine/chemistry , Symporters , Tumor Suppressor Proteins/chemistry , Tumor Suppressor Proteins/metabolism

19.

Of Juno, neuropeptide release, and light-activated chloride channels.

Adler, Elizabeth M.

J Gen Physiol ; 143(6): 657-8, 2014 Jun.

Article in English | MEDLINE | ID: mdl-24863928

Subject(s)

Calcium/metabolism , Intracellular Membranes/metabolism , Ion Channel Gating/physiology , Neuropeptides/metabolism , Pituitary Gland, Posterior/metabolism , Ryanodine Receptor Calcium Release Channel/metabolism , Secretory Vesicles/metabolism , Animals

20.

Of pumps, protons, chloride gradients, and microvesicles at the immunological synapse.

Adler, Elizabeth M.

J Gen Physiol ; 143(4): 417-8, 2014 Apr.

Article in English | MEDLINE | ID: mdl-24688015

Subject(s)

Proton Pumps/chemistry , Proton Pumps/metabolism , Sodium-Potassium-Exchanging ATPase/chemistry , Sodium-Potassium-Exchanging ATPase/metabolism , Xenopus Proteins/chemistry , Xenopus Proteins/metabolism , Animals , Female

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