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Gastroenterology ; 68(3): 534-44, 1975 Mar.
Article in English | MEDLINE | ID: mdl-1112455

ABSTRACT

Renal excretion of bile salts was studied in 17 patients with cirrhosis of the liver. The average quantity of bile salts in urine was 10.2 plus or minus 8.3 mg per 24 hr, 56% of which were sulfated. Of the individual urinary bile salts, 24% oithocholate were sulfated. In contrast, neither sulfated nor nonsulfated bile salts could be detected in urine from 2 normal subjects. Kinetics of bile salt metabolism was measured in 2 of the cirrhotic patients after oral administration of [14C] cholate and [3H] chenodeoxycholate. Approximately 3 to 12% of bile salts synthesized in liver were excreted in urine. Most urinary bile salts (76 to 80%) were sulfated, whereas only 4 to 5% of serum bile salts and 7 to 10% of biliary bile salts were sulfated. Renal clearance of cholate was more than 3 times greater than the clearance of chenodeosycholate or deoxycholate. Renal clearance of sulfated bile salts was 20 to 200 times greaterthan the clearance of the corresponding nonsulfated bile salts.


Subject(s)
Bile Acids and Salts/metabolism , Liver Cirrhosis/metabolism , Sulfates/metabolism , Adult , Bile Acids and Salts/urine , Carbon Radioisotopes , Chenodeoxycholic Acid/blood , Chenodeoxycholic Acid/metabolism , Chenodeoxycholic Acid/urine , Cholic Acids/blood , Cholic Acids/metabolism , Cholic Acids/urine , Chromatography, Gas , Deoxycholic Acid/blood , Deoxycholic Acid/metabolism , Deoxycholic Acid/urine , Humans , Kinetics , Lithocholic Acid/blood , Lithocholic Acid/metabolism , Lithocholic Acid/urine , Liver Cirrhosis/blood , Liver Cirrhosis/urine , Middle Aged , Spectrophotometry, Infrared , Sulfates/urine , Tritium
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