ABSTRACT
Renal function was assessed in 8 males at reproductive age suffering from lupus nephritis (LN). Normal renal function was registered in 5 patients, hypofunction in 3 males. Endocrinological examinations (evaluation of secondary sexual characters, of hypophyseal and sex hormone profile, sexological questionnaires, spermograms) failed to distinguish significant differences between SLE males and renal patients without SLE suffering from hypogonadism (13 males with uremic hypogonadism, 10 males with azoospermia induced by cytostatics). Endocrinological changes revealed may result from uremia and immunodepressive therapy. In 5 patients these abnormalities were corrected by parlodel and zinc sulfate. The authors came to the conclusion that feminization is not universal in LN males.
Subject(s)
Endocrine Glands/physiopathology , Lupus Nephritis/physiopathology , Adolescent , Adult , Chronic Disease , Erectile Dysfunction/etiology , Erectile Dysfunction/physiopathology , Humans , Hypogonadism/physiopathology , Immunosuppressive Agents/therapeutic use , Infertility, Male/physiopathology , Lupus Nephritis/complications , Lupus Nephritis/drug therapy , Male , Oligospermia/etiology , Oligospermia/physiopathology , Uremia/physiopathologyABSTRACT
The paper reports 3 cases of physical and sexual retardation in girls aged 14-22 with nephropathy: 1 girl had uremia in a conservative stage, 1 patient was put on a chronic hemodialysis for terminal uremia, 1 girl received a renal transplant. In response to combined treatment (zinc sulfate+parlodel) in the former two patients and norcolute therapy in the latter one body mass and growth increased in all the 3. The discussion is concerned with mechanisms of developmental defects in nephropathies, comparative efficacy of the drugs used and social rehabilitation of nephropathy girls with small height and sexual infantilism.
