ABSTRACT
In a brief review of 50-year scientific activity of professor N. N. Sirotinin and his students the authors emphasize that this broad-minded scientist contributed to development of such disciplines as microbiology, pathophysiology, high-altitude, aerospace medicine. However, his main goal was evolution of reactivity and resistance, approaches to perfection of human health and performance. Much attention was paid to effects of low partial oxygen pressure on human and animal body, to hypoxic states of different origin. Methods of hypoxytherapy and hypoxic training are widely used in Russia and abroad. The contribution of academician N. N. Sirotinin to modern pathophysiology, high-altitude and aerospace physiology, internal and sport medicine is highly appreciated in Russia.
Subject(s)
Aerospace Medicine/history , History, 20th Century , Internal Medicine/history , Physiology/history , Russia (Pre-1917) , Sports Medicine/history , USSR , UkraineSubject(s)
Neuroimmunomodulation/drug effects , Receptors, Antigen/drug effects , Receptors, Cholinergic/drug effects , Animals , Cell Membrane/drug effects , Cell Membrane/immunology , Ligands , Lymphocytes/drug effects , Lymphocytes/immunology , Neuroimmunomodulation/immunology , Receptors, Antigen/immunology , Receptors, Cholinergic/immunologySubject(s)
Anaphylaxis/immunology , Hypothalamus/immunology , Immunocompetence/immunology , Neuroimmunomodulation/immunology , Receptors, Neurotransmitter/immunology , Anaphylaxis/blood , Animals , B-Lymphocytes/immunology , Humans , Hypothalamus/drug effects , Interleukin-1/administration & dosage , Interleukin-2/administration & dosage , Interleukin-6/administration & dosage , Neuroimmunomodulation/drug effects , Receptors, Cholinergic/immunologyABSTRACT
Skin reaction on phytohemagglutinin in healthy people and in patients with allergic bronchial asthma before and after specific hyposensitization has been studied. The attempt to determine interrelations between the skin sensitivity to phytohemagglutinin and some immunity indexes and to explain several links of lectins' action mechanisms during allergic processes have been made.
Subject(s)
Asthma/immunology , Lectins/physiology , Phytohemagglutinins , Adult , Asthma/microbiology , Asthma/therapy , B-Lymphocytes , Desensitization, Immunologic , Female , Humans , Immunoglobulins/blood , Leukocyte Count , Male , Middle Aged , Neisseria/physiology , Reference Values , Skin Tests , Staphylococcus aureus/physiology , T-LymphocytesABSTRACT
Influence of macromolecular agents (some agents) on cholinoreceptors' activity of lymphocytes' membranes and their ability to bind with acetylcholine and it's analogues (carbacholine and others) has been investigated. This work presents the materials to problem of receptors' interaction and express one of the immunopharmacological characteristics of "receptor-receptor" system.
Subject(s)
Lymphocytes , Receptors, Cholinergic/immunology , Receptors, Immunologic/physiology , Acetylcholine/analogs & derivatives , Acetylcholine/metabolism , Animals , Antibody Formation , Cell Membrane/immunology , Epitopes , Immunization , Lymphocytes/ultrastructure , Mice , Mice, Inbred BALB C , Receptors, Cholinergic/metabolismSubject(s)
Allergens/administration & dosage , Anaphylaxis/immunology , Animals , Drug Carriers , Guinea Pigs , LiposomesSubject(s)
Allergens/adverse effects , Native Hawaiian or Other Pacific Islander , Railroads , Adolescent , Adult , Child , Humans , Hypersensitivity/epidemiology , Hypersensitivity/etiology , Middle Aged , Native Hawaiian or Other Pacific Islander/statistics & numerical data , Prevalence , Racial Groups , Siberia/epidemiologySubject(s)
Anaphylaxis/diagnosis , Arthropod Venoms/adverse effects , Drug Hypersensitivity/diagnosis , Railroads , Respiratory Hypersensitivity/diagnosis , Adolescent , Adult , Age Factors , Aged , Anaphylaxis/epidemiology , Anaphylaxis/etiology , Child , Drug Hypersensitivity/epidemiology , Drug Hypersensitivity/etiology , Female , Humans , Male , Middle Aged , Respiratory Hypersensitivity/epidemiology , Respiratory Hypersensitivity/etiology , Sex Factors , Siberia/epidemiology , Surveys and QuestionnairesABSTRACT
The effect of rabbit antiserum to mice globulins on the M-cholinergic receptors (M-ChR) expression of spleen B-lymphocytes of CBA and Balb/c mice has been studied. Anti-globulin antiserum depending on its concentration decreased M-Chr expression on B-lymphocytes intact animals both species. The anti-globulin serum effect appeared to be maximal at 37 degrees C and minimal at 4 degrees C. The date obtained suggests a possible interaction between the immunoglobulin (antigen binding) and the neuromediator receptors of B-lymphocytes which may appear to be one of the mechanisms of interrelationship of the nervous and immune system at the cellular level.
Subject(s)
B-Lymphocytes/metabolism , Receptors, Immunologic/metabolism , Receptors, Muscarinic/metabolism , Animals , Antibodies, Anti-Idiotypic/immunology , B-Lymphocytes/immunology , Female , Immune System/physiology , Mice , Mice, Inbred BALB C , Mice, Inbred CBA , Nervous System Physiological Phenomena , Quinuclidinyl Benzilate , Spleen/cytologyABSTRACT
It was shown that increases of cAMP levels before and after adrenaline (10(-6) mol/liter) and cAMP levels before and after acetylcholine (10(-6) mol/liter) occur in mouse spleen B-lymphocytes in 2-3 and 3-6 days, respectively, after immunization with ovalbumin. Using radiolabeled blockers of these neuroreceptors, it was shown that their receptors on B-lymphocytes increase 3 and 3-4 days, respectively, after immunization. The data indicate that increases of spleen B-lymphocyte reactivity to neuromediators occur during an immune reaction associated, in part, with increases in the expression of their receptors.
