ABSTRACT
Diffuse plane xanthoma is a group of plane xanthomas that appear as yellow to yellowish-brown flat patches or slightly elevated plaques with a widespread distribution. It is often associated with, or preceded by several years of, hematologic problems. Here, we describe a 63-year-old woman diagnosed with diffuse normolipemic plane xanthoma who developed multiple myeloma 20 years later. This case suggests that patients with diffuse normolipemic plane xanthoma should be followed for their entire life to detect health problems.
Subject(s)
Female , Humans , Middle Aged , Multiple Myeloma , XanthomatosisABSTRACT
Diffuse plane xanthoma is a group of plane xanthomas that appear as yellow to yellowish-brown flat patches or slightly elevated plaques with a widespread distribution. It is often associated with, or preceded by several years of, hematologic problems. Here, we describe a 63-year-old woman diagnosed with diffuse normolipemic plane xanthoma who developed multiple myeloma 20 years later. This case suggests that patients with diffuse normolipemic plane xanthoma should be followed for their entire life to detect health problems.
Subject(s)
Female , Humans , Middle Aged , Multiple Myeloma , XanthomatosisABSTRACT
Lymphocytic infundibuloneurohypophysitis is a neuroendocrine disorder characterized by autoimmune inflammation of the pituitary stalk and neurohypophysis. Clinical findings such as acute onset central diabetes insipidus and the regression of characteristic magnetic resonance imaging (MRI) findings allow for the possible diagnosis of this disease. Three cases of lymphocytic infundibuloneurohypophysitis have been previously reported in Korea. Here we report a case in a 66-year-old woman, along with a review of previously reported occurrences in Korea. A woman presented with abrupt-onset central diabetes insipidus. Sella MRI showed thickening of the pituitary stalk and loss of high T1 signals that are associated with a normal neurohypophysis. Basal pituitary hormone levels were normal with the exception of growth hormone, which was low. The patient refused transsphenoidal pituitary biopsy and we thus chose to continue close clinical and radiologic follow-up after desmopressin nasal spray application. The need for desmopressin decreased slightly over time and MRI obtained after 6 months showed regression of the pituitary stalk lesion.
