[Tall stature and its correction in girls]. / Vysokoroslost' i ee korrektsiia u devochek.

The paper presents a classification of tall stature and clinical and hormonal findings in 35 girls in the age range of 11 to 18 years with constitutional tall stature. They showed a normal decline in growth hormone (GH) concentrations in the second phase of pubertal maturation. Concentrations of GH clearly correlated with the menstrual status. They were low in regularly menstruating girls, higher in non-menstruating girls and highest in tall girls with irregular menstrual cycles. Estrogen therapy in 7 girls decelerated growth rates and promoted epiphyseal ossification. Regular menstrual cycles established after withdrawal of therapy in all patients.

[Polycystic ovary syndrome with excess of prolactin]. / Sindrom polikistoznykh iaichnikov s povyshenniem urovnem prolaktina.

Therapy including parlodel, dexamethasone, clomiphene, norcolut and various combinations of these has been used in order to restore reproductive function of patients with polycystic ovary syndrome and hyperprolactinemia. Pregnancy was induced in 42.3% of the patients, with drug combinations employed in most cases. Application of one of the agents alone was inefficient.

[The importance of rehabilitation therapy for the outcome of a subsequent pregnancy in women with spontaneous abortion and hyperandrogenism]. / Znachenie reabilitatsionnoi terapii dlia iskhoda posleduiushchei beremennosti u zhenshchin s nevynashivaniem i giperandrogeniei.

A complex clinical-hormonal examination was conducted in 140 women most of whom suffered from habitual abortion and hyperandrogenicity (HA). Based on the clinical findings, determination of the basal hormone level, and functional tests the patients were divided into 3 groups: 1) patients with predominantly adrenal HA (30 per cent); 2) patients with mainly ovarian HA (12.1 per cent), and 3) patients with an abnormally high level of androgens of ovarian-adrenal origin (57.9 per cent). The peculiarities of the clinical and hormonal parameters in patients of the three groups as well as the pathogenetic therapy aimed at preparation for pregnancy prolongation to term and birth of a viable neonate.

[Laparoscopic picture in patients with oligomenorrhea treated for chronic salpingo-oophoritis]. / Laparoskopicheskaia kartina u bo'lnykh s oligomenoreei, lechivshikhsia po povodu khronicheskogo sa'lpingooforita.

Sixty patients with oligomenorrhea and the painful syndrome were examined to study the course of a chronic inflammatory process of the genitals. Laparoscopy has confirmed the initial diagnosis of salpingo-oophoritis in 24 of the 60 examinees. The authors call for a more thorough examination of this patient population, for an erroneous diagnosis of a chronic inflammation leads to erroneous therapeutic strategy, consisting in irrational administration of antibacterial, balneo- and physiotherapy.

[Use of difenin in the treatment of constitutionally tall girls]. / Primenenie difenina v lechenii konstitutsional'noi vysokoroslosti u devochek.

Thirteen constitutionally tall girls marked by certain retardation of sexual development, confirmed by clinical, instrumental and laboratory studies were examined. The girls' age ranged within 11 to 15 years. The examinations were performed before and during phenytoin treatment. The data obtained indicate that during phenytoin treatment, increment of the body length decreased to 1-3 cm over one year; skeletal maturation was found to be accelerated by 2-5 years. In 8 patients, menstruations occurred by themselves and in 5, the menstrual cycle returned to normal. The rise of the content of follicle-stimulating and somatotropic hormones as well as of estradiol together with a tendency towards cortisol content lowering were recorded. Based on the studies performed it may be ascertained that the use of phenytoin inhibits the growth rate, accelerates the closing of the zones of bone growth, promotes normalization of menstrual function, and expedites menarche.