[The combined treatment of locally disseminated pancreatic cancer using cryosurgery]. / Kombinirovannoe lechenie mestno-rasprostranennogo raka podzheludochnoi zhelezy s ispol'zovaniem kriokhirurgii.

Experimental cryodestruction of the pancreas performed in 40 dogs served as a basis for selecting the temperature regimen, exposure time and extent of treatment to be subsequently used in man. Cryodestruction and combined cryoradiotherapy were employed in 30 patients with locally advanced pancreatic cancer. The procedure proved effective as it assured alleviation of pain, improvement in performance status and an increase in survival. CA-19-9 level and T-lymphocyte count were followed. These markers may be used to predict progression of pancreatic cancer.

[The diagnostic information value of determining tumor-associated antigen Ca-19-9 in pancreatic cancer]. / Diagnosticheskaia informativnost' opredeleniia opukholeassotsiirovannogo antigena Ca-19-9 pri rake podzheludochnoi zhelezy.

Clinical utility of radioimmunologic assessment of blood tumor-associated CA-19-9 antigen level was evaluated in 225 cases of various biliopancreatoduodenal pathology. The levels exceeded the discriminating value of 40 U/ml in 96.4% of patients with pancreatic cancer (mean - 641.7 U/ml), specifically, in those radically operated on for tumors 3 cm in diameter or larger. Application of this noninvasive method for screening for resectable pancreatic carcinoma is justified.

[Carcinoembryonic antigen and hormonal polypeptides in patients with lung cancer]. / Rakovo-émbrional'nyi antigen i gormonal'nye polipeptidy u bol'nykh rakom legkogo.

The paper is concerned with the evaluation of the diagnostic value of a tumor marker complex determined by in vitro analysis at primary diagnosis of lung cancer, during early postoperative follow-up and subsequent monitoring for early detection of disease progression.

[Parathyrin content of lung cancer patients undergoing surgical and chemotherapeutic treatment]. / Soderzhanie paratirina u bol'nykh rakom legkogo pri operativno-khimioterapevticheskom lechenii.

Parathyrin concentration was determined in lung cancer patients prior to and after operation by using a radiological method. A preoperative elevated level of parathyrin was noted in 60.4% of the patients. Radical surgery resulted in the return of the parathyrin level to normal, and toxic effects caused by chemotherapy were accompanied by its sharp increase. A similar increase in the parathyrin level attends generalization of a tumor process.

[Carcinoembryonic antigen in lung cancer patients]. / Rakovo-émbrional'nyi antigen u bol'nykh rakom legkogo.

Radioimmunoassay of carcino-embryonic antigen was conducted in lung cancer patients before and after surgery. Elevated concentrations of the antigen before operation was registered in 84.8% of cases. Antigen levels returned to normal after radical removal of tumor and rose sharply as a result of chemotherapy toxicity. A similar pattern of changes in carcino-embryonic antigen level was observed in cases of disseminated and recurrent cancer.

[Functional activity of the hypophyseal-thyroid system in oncological patients]. / Funktsional'naia aktivnost' gipofizarno-tireoidnoi sistemy u onkologicheskikh bol'nykh.

Studies of the hypophyseal-thyroid system in patients with cancer of the lung, stomach, mammary gland have revealed similar changes, manifested in the increased TTH concentration with simultaneous fall in the T3 and T4 content with the resultant increase of TTH/T3 and TTJ/T4 coefficients. The changes observed are characteristic of oncological patients only and may be used for diagnostic purposes.