ABSTRACT
Broad-spectrum antibiotics from the fluoroquinolone family have emerged as prominent water contaminants, among other pharmaceutical pollutants. In the present study, an antibacterial magnetic molecularly imprinted polymer (MMIP) composite was successfully fabricated using carboxy methyl dextrin grafted to poly(aniline-co-meta-phenylenediamine) in the presence of Fe3O4/CuO nanoparticles and ciprofloxacin antibiotic. The characteristics of obtained materials were investigated using FTIR, XRD, VSM, TGA, EDX, FE-SEM, zeta potential, and BETanalyses. Afterward, the MMIP's antibacterial activity and adsorption effectiveness for removing ciprofloxacin from aqueous solutions were explored. The results of the antibacterial tests showed that MMIP had an antibacterial effect against Escherichia coli, a Gram-negative pathogen (16 mm), and Staphylococcus aureus, a Gram-positive pathogen (22 mm). Adsorption efficacy was evaluated under a variety of experimental conditions, including solution pH, adsorbent dosage, contact time, and initial concentration. The maximum adsorption capacity (Qmax) of the MMIP for ciprofloxacin was determined to be 1111.1 mg/g using 3 mg of MMIP, with an initial concentration of 400 mg/L of ciprofloxacin at pH 7, within 15 min, and agitated at 25 °C, and the experimental adsorption results were well-described by the Freundlich isotherm model. The adsorption kinetic data were well represented by the pseudo-second-order model. Electrostatic interaction, cation exchange, π-π interactions, and hydrogen bonding were mostly able to adsorb the majority of the ciprofloxacin onto the MMIP. Adsorption-desorption experiments revealed that the MMIP could be retrieved and reused with no noticeable reduction in adsorption efficacy after three consecutive cycles.
ABSTRACT
Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles.
