ABSTRACT
The experimental work performed in 6 dogs was aimed at studying the dynamics of morphological alterations of the interatrial septum (IAS) tissues in the place of occlusion of the endovascular appliance ("ASO") and around it on the right and left atrium side at different terms after operation. A defect of the animals' interatrial septum in the area of the oval fossa was modeled artificially and then abolished with the "ASO". No substantial differences were revealed between processes of organization of thrombotic masses and formation of the endothelium on the "ASO" from both atria. The endothelium on the micropreparations on the "ASO" surfaces was formed as early as by the 14th day after its implantation in the heart IAS.
Subject(s)
Balloon Occlusion/instrumentation , Heart Septal Defects, Atrial/therapy , Heart Septum/pathology , Prostheses and Implants , Animals , Dogs , Heart Septal Defects, Atrial/pathologyABSTRACT
Changed size and forms of the right and left ventricles of the heart and intraventricular hemodynamics were studied in 5 patients after closing the defects of the interventricular septum with an intravascular device. It was found that after occlusion of the defects by the safe and atraumatic endovascular device the right ventricular myocardium of the heart relaxed, the stroke index became less, the ejection fraction became greater, the diastolic diameter of the right ventricle decreased, and of the left ventricle increased. The indices of the regional contraction function of the tri-cuspid and output sectors of the input part and external and pulmonary output sectors of the right ventricle were found to normalize.
