ABSTRACT
This paper deals with one of the most promising methods for the assessment of the health status of pregnant women and their children based on information criteria in the framework of an intelligent system. Inter-relations between the revealed adaptation strategies and functional disturbances in the organism are considered with special reference to various types of adaptive reactions in pregnant women and adaptational capacities of their children.
Subject(s)
Adaptation, Physiological , Breathing Exercises , Exercise Therapy/methods , Gymnastics , Hydrotherapy/methods , Pregnancy Complications/prevention & control , Adult , Data Interpretation, Statistical , Female , Humans , Hydrocortisone/blood , Insulin/blood , Malondialdehyde/blood , Pregnancy , Pregnancy Complications/blood , Pregnancy Complications/physiopathology , Pregnancy Outcome , Treatment Outcome , Vitamin E/blood , Young AdultABSTRACT
The association of a ratio of blood porphyrin fraction concentrations in pregnant women with hyperandrogenism (HA) with the osmoresistance of red blood cells and the microviscosity of their membranes was studied. A cohort examination was made in parallel groups of 64 pregnant women aged 20 to 30 years at 28-36 weeks gestation. The levels of dehydroepiandrosterone sulfate (DHEAS) and testosterone were measured. External cardiotocography, ultrasonography, and Doppler study were conducted. The blood concentrations of endogenous protoporphyrin (PP) and coproporphyrin (CP) were estimated by the spectral fluorescence technique. Erythrocytic membrane microviscosity was determined from the degree of pyrene eximeration, by measuring the fluorescence spectra; erythrocytic osmoresistance was ascertained by the procedure developed by N. L. Vasilevskaya. The pregnant women with placental insufficiency in the presence of HA were found to have an altered ratio of the concentrations of erythrocytic porphyrin fractions, which enhanced the microviscosity and resistance of red blood cell membranes, causing worse microcirculation. There was an inverse correlation between the level of DHEAS and the ratio of the concentrations of endogenous PP to CP. It is concluded that the development of placental insufficiency in pregnant women with HA is attended by the decreased ratio of PP to CP along with the higher microviscous characteristics of erythrocytic membranes and the lower amplitude of their osmoresistance, by increasing the lower osmoresistance range.
Subject(s)
Hyperandrogenism/complications , Placental Circulation/physiology , Placental Insufficiency/etiology , Porphyrins/metabolism , Adult , Case-Control Studies , Dehydroepiandrosterone Sulfate/blood , Dexamethasone/administration & dosage , Dexamethasone/therapeutic use , Erythrocyte Membrane/metabolism , Female , Gestational Age , Humans , Hyperandrogenism/blood , Hyperandrogenism/drug therapy , Hyperandrogenism/metabolism , Hyperandrogenism/physiopathology , Osmotic Fragility , Placental Insufficiency/metabolism , Pregnancy , Testosterone/blood , Young AdultABSTRACT
Activities of estrogen metabolism enzymes (aromatase, 2- and 4-estrogen hydroxylases, catechol-O-methyltransferase, and glutathione transferase) were studied by modern biochemical methods in tumors of patients with endometrial cancer. Relationships between enzyme activities and body weight index, age of menarche, stage of the disease, tumor histotype, differentiation degree, and depth of invasion into the myometrium were detected. The detected relationships between enzyme activities and serum concentrations of estradiol and progesterone and level of estrogen receptors in tumor tissue attest to hormone dependence of aromatase, estrogen hydroxylases, and glutathione transferase.
