ABSTRACT
Endometriosis of abdominal wall scar following operation on uterus and tubes is extremely rare. The late onset of symptoms after surgery is the usual cause of misdiagnosis. Scar endometriosis is a rare disease which is difficult to diagnose and should always be considered as a differential diagnosis of painful abdominal masses in women. The diagnosis is made only after excision and histopathology of the lesion. Preoperative differentials include hernia, lipoma, suture granuloma or abscess. Hence an awareness of the entity avoids delay in diagnosis, helps clinicians to a more tailored treatment and also avoids unnecessary referrals. We report a case of abdominal endometriosis. The definitive diagnosis of which was established by histopathological studies.
Subject(s)
Abdominal Wall/pathology , Cesarean Section/adverse effects , Cicatrix/pathology , Endometriosis/pathology , Adult , Female , HumansABSTRACT
Chromosomal fragile sites are distributed all over the human genome. Aphidicolin mediated expression frequency of common fragile sites and other chromosomal changes were evaluated in prometaphase/metaphase chromosomes obtained from peripheral blood lymphocytes of colorectal cancer patients. The present study reveals first time high incidence i.e. 6 % of aphidicolin induced chromosome breaks / gaps designated as "common fragile sites" in cell population of clinically diagnosed patients of colorectal cancer patients in Nepalese population. These chromosomal changes including structural and numerical were compare to clinically healthy normal individual of same sex / age groups, act as controls for statistical analysis. The frequency of chromosomal aberration in cancer patients were significantly higher (p<0.001) when compare to normal individuals. The increased genetics instability probably either due to nutritional factor i.e. lack of folic acid component in diet--an essential component required for DNA synthesis or unknown environmental factor for such genetic disorder. The present study indicates aphidicolin high frequency of induced chromosome aberrations and "common fragile sites" because of late replication of DNA in mitosis in colorectal cancer patients suggesting these sites could be used as suitable marker for determining genetic predisposition in cancer patients.
Subject(s)
Aphidicolin/pharmacology , Chromosome Aberrations , Chromosome Fragile Sites , Colorectal Neoplasms/genetics , Lymphocytes/ultrastructure , Humans , Middle AgedABSTRACT
The viral encephalitis epidemic during 2000 involved all the seven districts of Upper Assam (with 96.4% cases). The epidemiological, serological, clinical and entomological observations of the epidemic confirmed it to be due to JE. These were analysed, presented and discussed in the light of past history/records of the disease in the state. The epidemic was confined to the peak monsoon months of July and August (96% of the cases in the past). Serologically, 75-90% cases were confirmed to be due to JE. Case fatality Rate was 42.11% (overall average of the state in the past). There was no difference in case incidence among children or adults. Male to female ratio was 1:0.6. Based on the abundance and host preferences during the transmission period as well as virus isolation studies (as per past studies in the area) the main vectors Culex vishnui and Mansonia annulifera were susceptible to 4% DDT.
Subject(s)
Disease Outbreaks , Encephalitis, Japanese/epidemiology , Adolescent , Adult , Age Distribution , Animals , Child , Disease Vectors , Encephalitis, Japanese/mortality , Female , Humans , Incidence , India/epidemiology , Male , Rural Health , Seasons , Sex DistributionABSTRACT
This interesting case deals with the possible origin of pituitary tumor from cell rests located outside the pituitary gland. In the present case we found an elderly lady presenting with a suspected mass lesion of the sphenoidal sinus, clinically suspected to be either an infective granuloma or a chordoma which finally turned out to be an adenoma of the pituitary gland.
